|Full name||Manuel Reina Rodríguez|
|Date of birth||1 April 1985|
|Place of birth||Villanueva del Trabuco, Spain|
|Height||1.85 m (6 ft 1 in)|
|* Senior club appearances and goals counted for the domestic league only and correct as of 23 April 2017.
Born in Villanueva del Trabuco, Málaga, Andalusia, Reina was a product of hometown Málaga CF's youth system. He appeared in one game with the first team during the 2005–06 season, against Valencia CF in a 0–0 home draw, as they went on to rank last in La Liga.
In 2007, Reina joined Levante UD, but played mainly for the reserves during his early spell. However, the club's severe financial crisis led to him becoming first-choice after the departure of Marco Storari; in eight matches, he conceded 18 goals.
Reina appeared in 47 games in the following two seasons combined, the last of them ending in top flight promotion. For 2010–11 he was initially deemed second-choice, to newly signed Gustavo Munúa. However, after the Uruguayan conceded ten goals in the first three matches, he was selected for the next two rounds, keeping clean sheets against UD Almería (0–1 away win) and Real Madrid (0–0, at home); he eventually lost his starting position again, finishing the campaign with 18 appearances as the Valencians eventually retained their top division status.
On 30 January 2013, Reina moved teams and countries again, signing with Superleague Greece club Atromitos F.C. as a replacement for PAOK FC-bound Charles Itandje. He was mostly a backup to Velimir Radman, and left in June after making no official appearances.
- Gonzalez strike ensures Levante get off the mark; ESPN Soccernet, 22 September 2010
- Lowly Levante knock Real off top spot; ESPN Soccernet, 25 September 2010
- El Cartagena anuncia cuatro fichajes (Cartagena announces four signings); Marca, 20 June 2011 (in Spanish)
- Ποδοσφαιριστής του Ατρόμητου ο Ρέινα (Reina footballer of Atromitos); Contra, 30 January 2013 (in Greek)
- Manuel Reina, presentat (Manuel Reina, presented); Gimnàstic Tarragona, 2 July 2013 (in Catalan)