An educationist, Godfrey for 17 years acted as the Superintendent-in-Charge of Examinations and Selections. She established The Catholic Association of Hyderabad. She was one of the two Anglo-Indian members nominated to the 5th Lok Sabha in 1971. Prior to that, she had been a nominated member of Andhra Pradesh Legislative Assembly for four years and a Vice President of All India Anglo-Indian Association's governing body.
Godfrey had also served on the Central Social Welfare Advisory Board and represented Andhra Pradesh at the Inter-State Board for Anglo-Indian Education.
On 10 January 1949, Marjorie was married to Allen Godfrey. The couple had two children. She died on 27 October 2003, due to cardiac arrest. Andhra Pradesh Council of Churches and The Catholic Association of Hyderabad condoled her death.