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Matrona may refer to:


  • Matryona Nikonova, known as Matrona of Moscow, a saint of the Russian Orthodox Church
  • Matrona of Barcelona, a saint of the Roman Catholic Church, born in Thessaloniki and venerated in Barcelona
  • Matrona of Chios, also known as Chiopolitissa, a 15th-century saint of the Orthodox Church, born in the island of Chios, Greece
  • Dea Matrona, a singular form of Matronae or Matrones, mother goddesses attested in the Roman era among Celtic and Germanic regions; see Matres and Matrones
  • St. Matrona of Perge, A fifth century saint of the Byzantine Church, born in the city of Perge Pamphylia (Asia Minor)