Migrating motor complex
Migrating motor complexes (or migrating myoelectric complex or migratory motor complex or migratory myoelectric complex or MMC) are waves of electrical activity that sweep through the intestines in a regular cycle during fasting. These motor complexes trigger peristaltic waves, which facilitate transportation of indigestible substances such as bone, fiber, and foreign bodies from the stomach, through the small intestine, past the ileocecal sphincter, and into the colon. The MMC occurs every 45–180 minutes during the interdigestive phase (i.e., between meals) and is responsible for the rumbling experienced when hungry. It also serves to transport bacteria from the small intestine to the large intestine and to inhibit the migration of colonic bacteria into the terminal ileum.
- Phase I – A prolonged period of quiescence;
- Phase II – Increased frequency of action potentials and smooth muscle contractility;
- Phase III – A few minutes of peak electrical and mechanical activity, and;
- Phase IV – Declining activity which merges with the next Phase I.
Trimebutine is one drug that as part of its therapeutic action causes a premature activation of phase III of the migrating motor complex in the digestive tract.
- Code, CF; Marlett, JA. "The interdigestive myo-electric complex of the stomach and small bowel of dogs". J Physiol. 246 (2): 289–309. PMC .
- Poitras, Pierre; Peeters, Theo L (February 2008). "Motilin". Current Opinion in Endocrinology, Diabetes and Obesity. 15 (1): 54–57. PMID 18185063. doi:10.1097/MED.0b013e3282f370af.
- Boron, Walter F.; et, al, eds. (2012). Medical physiology : a cellular and molecular approach (Updated second ed.). Philadelphia, Pa.: Saunders. ISBN 978-1437717532.
- Lewis, TD (November 1999). "Morphine and gastroduodenal motility.". Digestive diseases and sciences. 44 (11): 2178–86. PMID 10573360.
- Hiyama, T.; Yoshihara, M.; Tanaka, S.; Haruma, K.; Chayama, K. (Apr 2009). "Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract." (PDF). J Gastroenterol Hepatol. 24 (4): 537–46. PMID 19220673. doi:10.1111/j.1440-1746.2009.05780.x.
- Overview at colostate.edu
- Physiology: 6/6ch2/s6ch2_26 - Essentials of Human Physiology
- Migrating motor complex at the US National Library of Medicine Medical Subject Headings (MeSH)