Mucus

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Mucous cells of the stomach lining secrete mucus (pink) into the lumen

Mucus (/ˈmjkəs/ MEW-kəs) is a polymer. It is a slippery aqueous secretion produced by, and covering, mucous membranes. It is typically produced from cells found in mucous glands, although it may also originate from mixed glands, which contain both serous and mucous cells. It is a viscous colloid containing inorganic salts, antimicrobial enzymes (such as lysozymes), immunoglobulins, and glycoproteins such as lactoferrin[1] and mucins, which are produced by goblet cells in the mucous membranes and submucosal glands. Mucus serves to protect epithelial cells in the linings of the respiratory, digestive, and urogenital systems, and structures in the visual, and auditory systems from pathogenic fungi, bacteria[2] and viruses. Most of the mucus in the body is produced in the gastrointestinal tract.

Amphibians, fish, hagfish, snails, slugs, and some other invertebrates also produce external mucus from their epidermis as protection against pathogens, and to help in movement. Mucus is also produced in fish to line their gills. Plants produce a similar substance called mucilage that is also produced by some microorganisms.[3]

Respiratory system[edit]

Illustration depicting the movement of mucus in the respiratory tract
SEM micrograph of the cilia projecting from respiratory epithelium in the trachea functioning in mucociliary clearance.

In the human respiratory system, mucus is part of the epithelial lining fluid (ELF) that lines most of the respiratory tract. The epithelial lining fluid consists of a sol layer termed the airway surface liquid, and this underlies a gel layer termed the mucus. The airway surface liquid layer is also known as the periciliary liquid layer as it surrounds the cilia. The airway surface liquid layer lies on top of the surface epithelium and is overlaid by the mucus layer.[4][5] The mucus blanket aids in the protection of the lungs by trapping foreign particles before they enter them, in particular, through the nose, during normal breathing.[6]

Phlegm is a specialized term for mucus that is restricted to the respiratory tract and coughed up as sputum. Nasal mucus describes secretions of the nasal passages. Nasal mucus is produced by the nasal mucosa. In the airways – the trachea, bronchi, and bronchioles, the mucus lining is produced by specialized airway epithelial cells called goblet cells, and submucosal glands. Small particles such as dust, particulate pollutants, and allergens, as well as infectious agents and bacteria are caught in the viscous nasal or airway mucus and prevented from entering the system. This process together with the continual movement of the cilia on the respiratory epithelium toward the oropharynx (mucociliary clearance), helps prevent foreign objects from entering the lungs during breathing. This explains why coughing often occurs in those who smoke cigarettes. The body's natural reaction is to increase mucus production. In addition, mucus aids in moisturizing the inhaled air and prevents tissues such as the nasal and airway epithelia from drying out.[7] Nasal and airway mucus is produced continuously, with most of it being swallowed subconsciously.

Upper respiratory tract[edit]

Increased mucus production in the upper respiratory tract is a symptom of many common ailments, such as the common cold, and influenza. Nasal mucus may be removed by blowing the nose or by using nasal irrigation. Excess nasal mucus, as with a cold or allergies, due to vascular engorgement associated with vasodilation and increased capillary permeability caused by histamines,[8] may be treated cautiously with decongestant medications. Thickening of mucus as a "rebound" effect following overuse of decongestants may produce nasal or sinus drainage problems and circumstances that promote infection.

During cold, dry seasons, the mucus lining nasal passages tends to dry out, meaning that mucous membranes must work harder, producing more mucus to keep the cavity lined. As a result, the nasal cavity can fill up with mucus. At the same time, when air is exhaled, water vapor in breath condenses as the warm air meets the colder outside temperature near the nostrils. This causes an excess amount of water to build up inside nasal cavities. In these cases, the excess fluid usually spills out externally through the nostrils.[9]

Lower respiratory tract[edit]

Excess mucus production known as mucus hypersecretion, in the bronchi and bronchioles, as may occur in asthma, bronchitis or influenza, results from chronic airway inflammation, and hence may be treated with anti-inflammatory medications. Impaired mucociliary clearance due to conditions such as primary ciliary dyskinesia may also result in its accumulation in the bronchi.[4] The dysregulation of mucus homesotasis is the fundamental characteristic of cystic fibrosis, an inherited disease caused by mutations in the CFTR gene, which encodes a chloride channel. This defect leads to the altered electrolyte composition of mucus, which triggers its hyperabsorption and dehydration. Such low-volume, viscous, acidic mucus has a reduced antimicrobial function, which facilitates bacterial colonisation.[10] The thinning of the mucus layer ultimately affects the PCL, which becomes dehydrated, compromising ciliary function and impairing mucociliary clearance.[4][10]

Digestive system[edit]

Gastric glands are composed of epithelial cells (B), chief cells (D), and parietal cells (E). The chief and parietal cells produce and secrete mucus (F) to protect the lining of the stomach (C) against the harsh pH of stomach acid. The mucus is basic, while the stomach acid (A) is acidic.

In the human digestive system, mucus is used as a lubricant for materials that must pass over membranes, e.g., food passing down the esophagus. Mucus is extremely important in the intestinal tract. It forms an essential layer in the colon and in the small intestine that helps reduce intestinal inflammation by decreasing bacterial interaction with intestinal epithelial cells.[11] A layer of mucus along the inner walls of the stomach is vital to protect the cell linings of that organ from the highly acidic environment within it.[scientific 1]

Reproductive system[edit]

In the human female reproductive system, cervical mucus prevents infection and provides lubrication during sexual intercourse. The consistency of cervical mucus varies depending on the stage of a woman's menstrual cycle. At ovulation cervical mucus is clear, runny, and conducive to sperm; post-ovulation, mucus becomes thicker and is more likely to block sperm. Several Fertility Awareness methods rely on observation of cervical mucus, as one of three primary fertility signs, to identify a woman's fertile time at the mid-point of the cycle. Awareness of the woman's fertile time allows a couple to time intercourse to improve the odds of pregnancy. It is also proposed as a method to avoid pregnancy. [12]

Clinical significance[edit]

In general, nasal mucus is clear and thin, serving to filter air during inhalation. During times of infection, mucus can change color to yellow or green either as a result of trapped bacteria[13] or due to the body's reaction to viral infection. The green color of mucus comes from the heme group in the iron-containing enzyme myeloperoxidase secreted by white blood cells as a cytotoxic defense during a respiratory burst.

In the case of bacterial infection, the bacterium becomes trapped in already-clogged sinuses, breeding in the moist, nutrient-rich environment. Sinusitis is an uncomfortable condition which may include congestion of mucus. A bacterial infection in sinusitis will cause discolored mucus and would respond to antibiotic treatment; viral infections typically resolve without treatment.[14] Almost all sinusitis infections are viral and antibiotics are ineffective and not recommended for treating typical cases.[15]

In the case of a viral infection such as cold or flu, the first stage and also the last stage of the infection cause the production of a clear, thin mucus in the nose or back of the throat. As the body begins to react to the virus (generally one to three days), mucus thickens and may turn yellow or green. Viral infections cannot be treated with antibiotics, and are a major avenue for their misuse. Treatment is generally symptom-based; often it is sufficient to allow the immune system to fight off the virus over time.[16]

Properties of mucus[edit]

Tunable swelling capacity[edit]

Mucus is able to absorb water or dehydrate through pH variations. The swelling capacity of mucus stems from the bottlebrush structure[17] of mucin within which hydrophilic segments provide a large surface area for water absorption. Moreover, the tunability of swelling effect is controlled by polyelectrolyte effect.

Polyelectrolyte effect in mucus[edit]

Polymers with charged molecules are called polyelectrolytes. Mucins, a kind of polyelectrolyte proteoglycans, are the main component of mucus, which provides the polyelectrolyte effect in mucus.[18] The process of inducing this effect comprises two steps: attraction of counter-ions and water compensation. When exposed in physiological ionic solution, the charged groups in the polyelectrolytes attract counter-ions with opposite charges, thereby leading to a solute concentration gradient. An osmotic pressure is introduced to equalize the concentration of solute throughout the system by driving water to flow from the low concentration areas to the high concentration areas. In short, the influx and outflux of water within mucus, managed by the polyelectrolyte effect, contribute to mucus' tunable swelling capacity.[19]

Mechanism of pH-tunable swelling[edit]

The ionic charges of mucin are mainly provided by acidic amino acids including aspartic acid (pKa=3.9) and glutamic acid (pKa=4.2). The charges of acidic amino acids will change with environmental pH value due to acid dissociation and association. Aspartic acid, for example, has a negative side chain when the pH value is above 3.9, while a neutrally charged side chain will be introduced as pH value drops below 3.9. Thus, the number of negative charges in mucus is influenced by the pH value of surrounding environment. That is, the polyelectrolyte effect of mucus is largely affected by the pH value of solution due to the charge variation of acidic amino acid residues on the mucin backbone. For instance, the charged residue on mucin is protonated at a normal pH value of the stomach, approximately pH 2. In this case, there is scarcely polyelectrolyte effect, thereby causing compact mucus with little swelling capacity. However, a kind of bacteria, Helicobacter pylori, is prone to producing base to elevate the pH value in stomach, leading to the deprotonation of aspartic acids and glutamic acids, i.e., from neutral to negative-charged. The negative charges in the mucus greatly increase, thus inducing the polyelectrolyte effect and the swelling of the mucus. This swelling effect increases the pore size of the mucus and decreases mucus' viscosity, which allows bacteria to penetrate and migrate into the mucus and cause disease.[20]

Charge selectivity[edit]

The high selective permeability of mucus plays a crucial role in the healthy state of human beings by limiting the penetration of molecules, nutrients, pathogens, and drugs. The charge distribution within mucus serves as a charge selective diffusion barrier, thus significantly affecting the transportation of agents. Among particles with various surface zeta potentials, cationic particles tend to have a low depth of penetration, neutral ones possess medium penetration, and anionic ones have the largest penetration depth. Furthermore, the effect of charge selectivity changes when the status of the mucus varies, i.e., native mucus has a threefold higher potential to limit agent penetration than purified mucus.[21]

Other animals[edit]

Mucus is also produced by a number of other animals. All fish are covered in mucus secreted from glands all over their bodies.[22] Invertebrates such as snails and slugs secrete mucus called snail slime to enable movement, and to prevent their bodies from drying out. Their reproductive systems also make use of mucus for example in the covering of their eggs.

See also[edit]

Notes[edit]

  1. ^ Purves, William. "Why don't our digestive acids corrode our stomach linings?". Scientific American. Retrieved 6 December 2012. Second, HCl in the lumen doesn't digest the mucosa because goblet cells in the mucosa secrete large quantities of protective mucus that line the mucosal surface.

References[edit]

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  2. ^ Barr et al. Bacteriophage adhering to mucus provide a non–host-derived immunity PNAS 2013
  3. ^ "Modes of locomotion in protists: 5 modes". biology discussion.
  4. ^ a b c Mall, MA (March 2008). "Role of Cilia, Mucus, and Airway Surface Liquid in Mucociliary Dysfunction: Lessons from Mouse Models". Journal of Aerosol Medicine and Pulmonary Drug Delivery. 21 (1): 13–24. doi:10.1089/jamp.2007.0659. PMID 18518828.
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  9. ^ "Why Does Cold Weather Cause Runny Noses?". NPR. Retrieved 2011-09-22.
  10. ^ a b Haq, Iram J; Gray, Michael A; Garnett, James P; Ward, Christopher; Brodlie, Malcolm (March 2016). "Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets". Thorax. 71 (3): 284–287. doi:10.1136/thoraxjnl-2015-207588. PMID 26719229.
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  13. ^ "Runny Nose (with green or yellow mucus)". Get Smart: Know When Antibiotics Work. Centers for Disease Control and Prevention. March 9, 2006. Archived from the original on March 8, 2008.
  14. ^ Consumer Reports; American Academy of Family Physicians (April 2012), "Treating sinusitis: Don't rush to antibiotics" (PDF), Choosing Wisely: an initiative of the ABIM Foundation, Consumer Reports, retrieved August 17, 2012
  15. ^ American Academy of Family Physicians, presented by ABIM Foundation, "Five Things Physicians and Patients Should Question" (PDF), Choosing Wisely: an initiative of the ABIM Foundation, American Academy of Family Physicians, archived from the original (PDF) on June 24, 2012, retrieved August 14, 2012
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  18. ^ Sircar, S.; Keener, J. P.; Fogelson, A. L. (2013-01-07). "The effect of divalent vs. monovalent ions on the swelling of Mucin-like polyelectrolyte gels: Governing equations and equilibrium analysis". The Journal of Chemical Physics. 138 (1): 014901. doi:10.1063/1.4772405. ISSN 0021-9606. PMC 3555968. PMID 23298059.
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