3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||293.272 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
N-Acetylmuramic acid, "NAM" or MurNAc, is the addition of phosphoenolpyruvate and N-acetylglucosamine with the chemical formula C
8. It is a key builder of peptidoglycan in the bacterial cell wall, which is built from alternating units of N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc), cross-linked by oligopeptides at the lactic acid residue of MurNAc.
MurNAc is a monosaccharide derivative of N-acetylglucosamine.
Formation of NAM
N-Acetylmuramic acid (MurNAc) is part of the peptidoglycan polymer of bacterial cell walls. MurNAc is covalently linked to N-acetylglucosamine and may also be linked through the hydroxyl on carbon number 4 to the carbon of L-alanine. A pentapeptide composed of L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine is added to the MurNAc in the process of making the peptidoglycan strands of the cell wall.
NAG and NAM cross-linking can be inhibited by antibiotics to inhibit pathogens from growing within the body. Therefore, both NAG and NAM are valuable polymers in medicinal research.