N-Nitrosodiethylamine
Appearance
Names | |
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Preferred IUPAC name
N,N-Diethylnitrous amide | |
Other names
N-Ethyl-N-nitrosoethanamine
Diethylnitrosamine DENA | |
Identifiers | |
3D model (JSmol)
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ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.000.206 |
EC Number |
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KEGG | |
MeSH | D004052 |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C4H10N2O | |
Molar mass | 102.137 g·mol−1 |
Appearance | Yellow liquid[1] |
Density | 0.95 g/mL[1] |
Boiling point | 177 °C (351 °F; 450 K)[1] |
-59.3·10−6 cm3/mol | |
Related compounds | |
Related compounds
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Diethylamine, N-Nitrosodimethylamine |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N-Nitrosodiethylamine is a carcinogenic and mutagenic[2] organic compound, classified as a nitrosamine. It is found in tobacco smoke.[3]
It is classified as a Group 2A carcinogen (probable human carcinogen) by the World Health Organization.[4]
N-Nitrosodiethylamine is a constituent of tobacco smoke.[5]
References
- ^ a b c "N-Nitrosodiethylamine". Sigma-Aldrich.
- ^ Verna, L; Whysner, J; Williams, G. M. (1996). "N-nitrosodiethylamine mechanistic data and risk assessment: Bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation". Pharmacology & Therapeutics. 71 (1–2): 57–81. doi:10.1016/0163-7258(96)00062-9. PMID 8910949.
- ^ Tricker, A. R.; Ditrich, C; Preussmann, R (1991). "N-nitroso compounds in cigarette tobacco and their occurrence in mainstream tobacco smoke". Carcinogenesis. 12 (2): 257–61. doi:10.1093/carcin/12.2.257. PMID 1995191.
- ^ "List of Classifications, Volumes 1-115". IARC Monographs on the Evaluation of Risk to Humans. International Agency for Research on Cancer. February 22, 2016. Retrieved July 26, 2016.
- ^ Talhout, Reinskje; Schulz, Thomas; Florek, Ewa; Van Benthem, Jan; Wester, Piet; Opperhuizen, Antoon (2011). "Hazardous Compounds in Tobacco Smoke". International Journal of Environmental Research and Public Health. 8 (12): 613–628. doi:10.3390/ijerph8020613. ISSN 1660-4601. PMC 3084482. PMID 21556207.
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