N-acetylmuramic acid 6-phosphate etherase
| N-acetylmuramic acid 6-phosphate etherase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.126 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
N-acetylmuramic acid 6-phosphate etherase (EC 4.2.1.126, MurNAc-6-P etherase, MurQ) is an enzyme with systematic name (R)-lactate hydro-lyase (adding N-acetyl-D-glucosamine 6-phosphate; N-acetylmuramate 6-phosphate-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (R)-lactate + N-acetyl-D-glucosamine 6-phosphate N-acetylmuramate 6-phosphate + H2O
This enzyme is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria.
References
- ^ Jaeger, T., Arsic, M. and Mayer, C. (2005). "Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase"". J. Biol. Chem. 280: 30100–30106. doi:10.1074/jbc.m502208200. PMID 15983044.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Uehara, T., Suefuji, K., Valbuena, N., Meehan, B., Donegan, M. and Park, J.T. (2005). "Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate". J. Bacteriol. 187: 3643–3649. doi:10.1128/jb.187.11.3643-3649.2005. PMID 15901686.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Uehara, T., Suefuji, K., Jaeger, T., Mayer, C. and Park, J.T. (2006). "MurQ etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall". J. Bacteriol. 188: 1660–1662. doi:10.1128/jb.188.4.1660-1662.2006. PMID 16452451.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Hadi, T., Dahl, U., Mayer, C. and Tanner, M.E. (2008). "Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling". Biochemistry. 47: 11547–11558. doi:10.1021/bi8014532. PMID 18837509.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Jaeger, T. and Mayer, C. (2008). "N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism". Cell. Mol. Life Sci. 65: 928–939. doi:10.1007/s00018-007-7399-x. PMID 18049859.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- N-acetylmuramic+acid+6-phosphate+etherase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)