N-acetyltransferase 1

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N-acetyltransferase 1 (arylamine N-acetyltransferase)
Protein NAT1 PDB 2DSS.png
Rendering based on PDB 2DSS.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NAT1 ; AAC1; MNAT; NAT-1; NATI
External IDs OMIM108345 HomoloGene37329 ChEMBL: 5101 GeneCards: NAT1 Gene
EC number 2.3.1.5
Orthologs
Species Human Mouse
Entrez 9 17961
Ensembl ENSG00000171428 ENSMUSG00000051147
UniProt P18440 P50295
RefSeq (mRNA) NM_000662 NM_001168577
RefSeq (protein) NP_000653 NP_001162049
Location (UCSC) Chr 8:
18.17 – 18.22 Mb
Chr 8:
67.49 – 67.5 Mb
PubMed search [1] [2]

N-acetyltransferase 1 (arylamine N-acetyltransferase) is a protein that in humans is encoded by the NAT1 gene.[1]

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat NAT2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].[1]

References[edit]

Further reading[edit]

  • Gubin, A. N.; Njoroge, J. M.; Bouffard, G. G.; Miller, J. L. (1999). "Gene Expression in Proliferating Human Erythroid Cells". Genomics 59 (2): 168–177. doi:10.1006/geno.1999.5855. PMID 10409428. 
  • Smelt, V. A.; Upton, A.; Adjaye, J.; Payton, M. A.; Boukouvala, S.; Johnson, N.; Mardon, H. J.; Sim, E. (2000). "Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos". Human Molecular Genetics 9 (7): 1101–1107. doi:10.1093/hmg/9.7.1101. PMID 10767335. 
  • Brockton, N.; Little, J.; Sharp, L.; Cotton, S. C. (2000). "N-acetyltransferase polymorphisms and colorectal cancer: A HuGE review". American Journal of Epidemiology 151 (9): 846–861. doi:10.1093/oxfordjournals.aje.a010289. PMID 10791558. 
  • Lo-Guidice, J. M.; Allorge, D.; Chevalier, D.; Debuysère, H.; Fazio, F.; Lafitte, L. J.; Broly, F. (2000). "Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay". Pharmacogenetics 10 (4): 293–300. doi:10.1097/00008571-200006000-00003. PMID 10862520. 
  • De León, J. H.; Vatsis, K. P.; Weber, W. W. (2000). "Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1". Molecular Pharmacology 58 (2): 288–299. PMID 10908296. 
  • Yu, M. W.; Pai, C. I.; Yang, S. Y.; Hsiao, T. J.; Chang, H. C.; Lin, S. M.; Liaw, Y. F.; Chen, P. J.; Chen, C. J. (2000). "Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: Impact of smoking on risk". Gut 47 (5): 703–709. doi:10.1136/gut.47.5.703. PMC 1728099. PMID 11034589. 
  • Wikman, H.; Thiel, S.; Jäger, B.; Schmezer, P.; Spiegelhalder, B.; Edler, L.; Dienemann, H.; Kayser, K.; Schulz, V.; Drings, P.; Bartsch, H.; Risch, A. (2001). "Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility". Pharmacogenetics 11 (2): 157–168. doi:10.1097/00008571-200103000-00006. PMID 11266080. 
  • Krajinovic, M.; Ghadirian, P.; Richer, C.; Sinnett, H.; Gandini, S.; Perret, C.; Lacroix, A.; Labuda, D.; Sinnett, D. (2001). "Genetic susceptibility to breast cancer in French-Canadians: Role of carcinogen-metabolizing enzymes and gene-environment interactions". International Journal of Cancer 92 (2): 220–225. doi:10.1002/1097-0215(200102)9999:9999<::AID-IJC1184>3.0.CO;2-H. PMID 11291049. 
  • Sekine, A.; Saito, A.; Iida, Y.; Mitsunobu, S.; Higuchi, S.; Harigae, Y.; Nakamura, S. (2001). "Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1 , NAT2 , AANAT , ARD1 , and L1CAM in the Japanese population". Journal of Human Genetics 46 (6): 314–319. doi:10.1007/s100380170065. PMID 11393533. 
  • Butler, W. J.; Ryan, P.; Roberts-Thomson, I. C. (June 2001). "Metabolic genotypes and risk for colorectal cancer". J. Gastroenterol. Hepatol. 16 (6): 631–635. doi:10.1046/j.1440-1746.2001.02501.x. PMID 11422615.