N-acetyltransferase 1

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Protein NAT1 PDB 2DSS.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases NAT1, AAC1, MNAT, NAT-1, NATI, N-acetyltransferase 1, N-acetyltransferase 1 (arylamine N-acetyltransferase)
External IDs MGI: 109201 HomoloGene: 37329 GeneCards: NAT1
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 8: 18.17 – 18.22 Mb Chr 8: 67.49 – 67.5 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

N-acetyltransferase 1 (arylamine N-acetyltransferase) is a protein that in humans is encoded by the NAT1 gene.[3]

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat NAT2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].[3]


Further reading[edit]

  • Gubin AN, Njoroge JM, Bouffard GG, Miller JL (July 1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. PMID 10409428. doi:10.1006/geno.1999.5855. 
  • Smelt VA, Upton A, Adjaye J, Payton MA, Boukouvala S, Johnson N, Mardon HJ, Sim E (April 2000). "Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos". Human Molecular Genetics. 9 (7): 1101–7. PMID 10767335. doi:10.1093/hmg/9.7.1101. 
  • Brockton N, Little J, Sharp L, Cotton SC (May 2000). "N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review". American Journal of Epidemiology. 151 (9): 846–61. PMID 10791558. doi:10.1093/oxfordjournals.aje.a010289. 
  • Lo-Guidice JM, Allorge D, Chevalier D, Debuysère H, Fazio F, Lafitte LJ, Broly F (June 2000). "Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay". Pharmacogenetics. 10 (4): 293–300. PMID 10862520. doi:10.1097/00008571-200006000-00003. 
  • de León JH, Vatsis KP, Weber WW (August 2000). "Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1". Molecular Pharmacology. 58 (2): 288–99. PMID 10908296. 
  • Yu MW, Pai CI, Yang SY, Hsiao TJ, Chang HC, Lin SM, Liaw YF, Chen PJ, Chen CJ (November 2000). "Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk". Gut. 47 (5): 703–9. PMC 1728099Freely accessible. PMID 11034589. doi:10.1136/gut.47.5.703. 
  • Wikman H, Thiel S, Jäger B, Schmezer P, Spiegelhalder B, Edler L, Dienemann H, Kayser K, Schulz V, Drings P, Bartsch H, Risch A (March 2001). "Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility". Pharmacogenetics. 11 (2): 157–68. PMID 11266080. doi:10.1097/00008571-200103000-00006. 
  • Krajinovic M, Ghadirian P, Richer C, Sinnett H, Gandini S, Perret C, Lacroix A, Labuda D, Sinnett D (April 2001). "Genetic susceptibility to breast cancer in French-Canadians: role of carcinogen-metabolizing enzymes and gene-environment interactions". International Journal of Cancer. 92 (2): 220–5. PMID 11291049. doi:10.1002/1097-0215(200102)9999:9999<::AID-IJC1184>3.0.CO;2-H. 
  • Sekine A, Saito S, Iida A, Mitsunobu Y, Higuchi S, Harigae S, Nakamura Y (2001). "Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population". Journal of Human Genetics. 46 (6): 314–9. PMID 11393533. doi:10.1007/s100380170065. 
  • Butler WJ, Ryan P, Roberts-Thomson IC (June 2001). "Metabolic genotypes and risk for colorectal cancer". Journal of Gastroenterology and Hepatology. 16 (6): 631–5. PMID 11422615. doi:10.1046/j.1440-1746.2001.02501.x.