NLGN4X

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NLGN4X
Protein NLGN4X PDB 2WQZ.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases NLGN4X, ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4, neuroligin 4, X-linked
External IDs HomoloGene: 136297 GeneCards: NLGN4X
RNA expression pattern
PBB GE NLGN4X 221933 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282145
NM_001282146
NM_020742
NM_181332

n/a

RefSeq (protein)

NP_001269074
NP_001269075
NP_065793
NP_851849

n/a

Location (UCSC) Chr X: 5.84 – 6.23 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Neuroligin-4, X-linked is a protein that in humans is encoded by the NLGN4X gene.[2][3]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462. 
  3. ^ a b "Entrez Gene: NLGN4X neuroligin 4, X-linked". 

Further reading[edit]