NONO (protein)

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This article is about non-POU domain-containing octamer-binding protein coding gene. For other uses, see nono (disambiguation).
Non-POU domain containing, octamer-binding
Protein NONO PDB 2cpj.png
PDB rendering based on 2cpj.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NONO ; NMT55; NRB54; P54; P54NRB; PPP1R114
External IDs OMIM300084 MGI1855692 HomoloGene7212 GeneCards: NONO Gene
RNA expression pattern
PBB GE NONO 208698 s at tn.png
PBB GE NONO 210470 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4841 53610
Ensembl ENSG00000147140 ENSMUSG00000031311
UniProt Q15233 Q99K48
RefSeq (mRNA) NM_001145408 NM_001252518
RefSeq (protein) NP_001138880 NP_001239447
Location (UCSC) Chr X:
71.28 – 71.3 Mb
Chr X:
101.43 – 101.45 Mb
PubMed search [1] [2]

Non-POU domain-containing octamer-binding protein is a protein that in humans is encoded by the NONO gene.[1][2][3]


NONO has been shown to interact with SFPQ,[4] SPI1[5] and Androgen receptor.[6]


  1. ^ Dong B, Horowitz DS, Kobayashi R, Krainer AR (Oct 1993). "Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6". Nucleic Acids Res. 21 (17): 4085–92. doi:10.1093/nar/21.17.4085. PMC 310009. PMID 8371983. 
  2. ^ Traish AM, Huang YH, Ashba J, Pronovost M, Pavao M, McAneny DB, Moreland RB (Dec 1997). "Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancer". Diagn. Mol. Pathol. 6 (4): 209–21. doi:10.1097/00019606-199708000-00005. PMID 9360842. 
  3. ^ "Entrez Gene: NONO Non-POU domain containing, octamer-binding". 
  4. ^ Peng R, Dye BT, Pérez I, Barnard DC, Thompson AB, Patton JG (Oct 2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341. PMID 12403470. 
  5. ^ Hallier M, Tavitian A, Moreau-Gachelin F (May 1996). "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb". J. Biol. Chem. 271 (19): 11177–81. doi:10.1074/jbc.271.19.11177. PMID 8626664. 
  6. ^ Ishitani K, Yoshida T, Kitagawa H, Ohta H, Nozawa S, Kato S (Jul 2003). "p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor". Biochem. Biophys. Res. Commun. 306 (3): 660–5. doi:10.1016/S0006-291X(03)01021-0. PMID 12810069. 

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