NOX5

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NOX5
Identifiers
Aliases NOX5
External IDs HomoloGene: 41568 GeneCards: NOX5
Genetically Related Diseases
obesity[1]
RNA expression pattern
PBB GE NOX5 220641 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001184779
NM_001184780
NM_024505

n/a

RefSeq (protein)

NP_001171708
NP_001171709
NP_078781

n/a

Location (UCSC) Chr 15: 68.93 – 69.06 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a protein which in humans is encoded by the NOX5 gene.[3][4]

Function[edit]

NOX5 is a novel NADPH oxidase that generates superoxide.[3]

Nox5 interacts with c-abl, superoxide production leads to phosphorylation of c-abl, while inhibition of c-abl kinase activity inhibits Nox5 superoxide production.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with NOX5 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ a b "Entrez Gene: NOX5 NADPH oxidase, EF-hand calcium binding domain 5". 
  4. ^ Bánfi B, Molnár G, Maturana A, Steger K, Hegedûs B, Demaurex N, Krause KH (October 2001). "A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes". J. Biol. Chem. 276 (40): 37594–601. doi:10.1074/jbc.M103034200. PMID 11483596. 
  5. ^ El Jamali A, Valente AJ, Lechleiter JD, Gamez MJ, Pearson DW, Nauseef WM, Clark RA (March 2008). "NOVEL REDOX-DEPENDENT REGULATION OF NOX5 BY THE TYROSINE KINASE C-ABL". Free Radic. Biol. Med. 44 (5): 868–81. doi:10.1016/j.freeradbiomed.2007.11.020. PMC 2278123Freely accessible. PMID 18160052. 

Further reading[edit]