NSAID hypersensitivity reactions

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

NSAID or nonsteroidal anti-inflammatory drug hypersensitivity reactions encompasses a broad range of allergic or allergic-like symptoms that occur within minutes to hours after ingesting aspirin or other NSAID nonsteroidal anti-inflammatory drugs. Hypersensitivity drug reactions differ from drug toxicity reactions in that drug toxicity reactions result from the pharmacological action of a drug, are dose-related, and can occur in any treated individual (see nonsteroidal anti-inflammatory drugs section on adverse reactions for NSAID-induced toxic reactions); hypersensitivity reactions are idiosyncratic reactions to a drug.[1] Although the term NSAID was introduced to signal a comparatively low risk of adverse effects,[2] NSAIDs do evoke a broad range of hypersensitivity syndromes. These syndromes have recently been classified by the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity.[3] The classification organizes the hypersensitivity reactions to NSAIDs into the following five categories:


  1. ^ Allergy Asthma Immunol Res. 2015 Jul;7(4):312-20. doi: 10.4168/aair.2015.7.4.312
  2. ^ Buer JK (Oct 2014). "Origins and impact of the term 'NSAID'". Inflammopharmacology. 22 (5): 263–7. doi:10.1007/s10787-014-0211-2. PMID 25064056. 
  3. ^ a b c Allergy. 2013 Oct;68(10):1219-32. doi: 10.1111/all.12260
  4. ^ Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):120-5. doi: 10.1016/j.prostaglandins.2008.12.003.
  5. ^ Respir Med. 2010 Oct;104(10):1404-9. doi: 10.1016/j.rmed.2010.04.017
  6. ^ Allergy. 2011 Jul;66(7):818-29. doi: 10.1111/j.1398-9995.2011.02557.x.
  7. ^ J Allergy Clin Immunol Pract. 2014 Nov-Dec;2(6):653-7. doi: 10.1016/j.jaip.2014.09.009
  8. ^ Curr Opin Allergy Clin Immunol. 2014 Feb;14(1):1-6. doi: 10.1097/ACI.0000000000000021
  9. ^ Immunol Allergy Clin North Am. 2013 May;33(2):163-76. doi: 10.1016/j.iac.2012.11.002
  10. ^ Curr Allergy Asthma Rep. 2015 Mar;15(3):508. doi: 10.1007/s11882-014-0508-7
  11. ^ Allergy. 2011 Jul;66(7):818-29. doi: 10.1111/j.1398-9995.2011.02557.x
  12. ^ J Allergy Clin Immunol 2003;111:882–888.
  13. ^ Curr Opin Allergy Clin Immunol 2009;9:305–310.