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Nevan Krogan

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Nevan Krogan
Academic background
EducationUniversity of Regina
University of Toronto
ThesisProtein complexes and epistatic mini-array profiles (E-MAPs) reveal pathways involved in chromatin function (2006)
Doctoral advisorJack Greenblatt
Academic work
InstitutionsUniversity of California San Francisco (UCSF)
J. David Gladstone Institutes

Nevan J. Krogan,[1] a Canadian molecular biologist. is a professor in the Department of Cellular and Molecular Pharmacology at the University of California San Francisco (UCSF), and a senior investigator at the J. David Gladstone Institutes. He is also the Director of the Quantitative Biosciences Institute, (QBI),[2] which focuses on developing and using quantitative approaches to study basic biological mechanisms, often related to disease areas. He serves as Director of The HARC Center, an NIH-funded collaborative group that focuses on the structural characterization of HIV-human protein complexes. Krogan's research is focused on using quantitative system approaches to help understand complex biological and biomedical problems. He has authored over 200 papers[3] in the field of molecular biology and has given over 200 lectures and seminars around the world.

Early life and education

Krogan obtained his undergraduate degree in chemistry from the University of Regina in 1997. Upon completing his M.Sc. in 1999 at the University of Regina, Krogan started his Ph.D. at the University of Toronto with Jack Greenblatt as his doctoral advisor.

During his PhD thesis, he led a project that systematically identified protein complexes in Saccharomyces cerevisiae through a tandem affinity purification/mass spectrometry (AP-MS) strategy. This led to the characterization of over 500 complexes, comprising more than 4000 proteins. During this time, he worked on developing an approach, termed E-MAP, for high throughput generation and quantitative analysis of genetic interaction data.[4] Combining the genetic and protein-protein interaction data led to a deeper understanding of the relationship between physical and genetic data[5] as well as insight into a wide variety of biological processes, including chromatin function, transcription, protein trafficking and RNA processing.[6][7][8][9]

Career

In July 2011, Krogan joined the Gladstone Institute of Virology and Immunology (GIVI) and Gladstone Institute of Cardiac Disease (GICD) as an associate investigator. In 2012, he led a comprehensive study using AP-MS to systematically identify protein-protein interactions between HIV and host cells.[10] 497 different HIV-human protein-protein interactions were identified,[11] only 19 of which had been previously reported in the literature. .[12]

Krogan was appointed director of the UCSF-QB3 in July 2013.[13] The same year, he was also promoted to senior investigator at the GIVI and GICD. He created the Thermo Fisher Scientific Mass Spectrometry Facility for Disease Target Discovery at the J. David Gladstone Institute and serves as its Director.[14] Krogan, along with Trey Ideker at UCSD, launched the Cancer Cell Map Initiative (CCMI) at UCSF in 2015.[15] The group, which includes many investigators at UCSF and UCSD, focuses on using systems approaches and network biology to interpret cancer genomic data.[16]

Awards and honors

  • 2004 – Hannah Farkas-Himsley and Alexander Memorial Award[citation needed]
  • 2005 – L. W. Macpherson Microbiology Award[citation needed]
  • 2008 – Top 25 authors of high-impact papers in molecular biology and genetics from 2002 to 2006[17]
  • 2009-2012 – Searle Scholar, Searle Foundation[18]
  • 2009-2014 – Keck Distinguished Young Scholar, W. M. Keck Foundation[citation needed]

References

  1. ^ "Krogan Lab". kroganlab.ucsf.edu. Retrieved 8 January 2018.
  2. ^ "UCSF Establishes Quantitative Biosciences Institute". UC San Francisco. Retrieved 2017-02-01.
  3. ^ "Nevan Krogan – Google Scholar Citations". scholar.google.com. Retrieved 2017-02-02.
  4. ^ Schuldiner, Maya; Collins, Sean R.; Thompson, Natalie J.; Denic, Vladimir; Bhamidipati, Arunashree; Punna, Thanuja; Ihmels, Jan; Andrews, Brenda; Boone, Charles (2005-11-04). "Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile". Cell. 123 (3): 507–519. doi:10.1016/j.cell.2005.08.031. ISSN 0092-8674. PMID 16269340.
  5. ^ Collins, Sean R.; Miller, Kyle M.; Maas, Nancy L.; Roguev, Assen; Fillingham, Jeffrey; Chu, Clement S.; Schuldiner, Maya; Gebbia, Marinella; Recht, Judith (2007-04-12). "Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map". Nature. 446 (7137): 806–810. doi:10.1038/nature05649. ISSN 1476-4687. PMID 17314980.
  6. ^ Krogan, Nevan J.; Peng, Wen-Tao; Cagney, Gerard; Robinson, Mark D.; Haw, Robin; Zhong, Gouqing; Guo, Xinghua; Zhang, Xin; Canadien, Veronica (2004-01-30). "High-definition macromolecular composition of yeast RNA-processing complexes". Molecular Cell. 13 (2): 225–239. doi:10.1016/s1097-2765(04)00003-6. ISSN 1097-2765. PMID 14759368.
  7. ^ Krogan, Nevan J.; Keogh, Michael-Christopher; Datta, Nira; Sawa, Chika; Ryan, Owen W.; Ding, Huiming; Haw, Robin A.; Pootoolal, Jeffrey; Tong, Amy (2003-12-01). "A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1". Molecular Cell. 12 (6): 1565–1576. doi:10.1016/s1097-2765(03)00497-0. ISSN 1097-2765. PMID 14690608.
  8. ^ Keogh, Michael-Christopher; Kurdistani, Siavash K.; Morris, Stephanie A.; Ahn, Seong Hoon; Podolny, Vladimir; Collins, Sean R.; Schuldiner, Maya; Chin, Kayu; Punna, Thanuja (2005-11-18). "Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex". Cell. 123 (4): 593–605. doi:10.1016/j.cell.2005.10.025. ISSN 0092-8674. PMID 16286008.
  9. ^ Keogh, Michael-Christopher; Kim, Jung-Ae; Downey, Michael; Fillingham, Jeffrey; Chowdhury, Dipanjan; Harrison, Jacob C.; Onishi, Megumi; Datta, Nira; Galicia, Sarah (2006-01-26). "A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery". Nature. 439 (7075): 497–501. doi:10.1038/nature04384. ISSN 1476-4687. PMID 16299494.
  10. ^ "How HIV Hijacks Host Cell Machinery | Protein Interactions Feature". BioTechniques. Retrieved 2017-02-01.
  11. ^ Jäger, Stefanie; Cimermancic, Peter; Gulbahce, Natali; Johnson, Jeffrey R.; McGovern, Kathryn E.; Clarke, Starlynn C.; Shales, Michael; Mercenne, Gaelle; Pache, Lars (2011-12-21). "Global landscape of HIV-human protein complexes". Nature. 481 (7381): 365–370. doi:10.1038/nature10719. ISSN 1476-4687. PMC 3310911. PMID 22190034.
  12. ^ Jäger, Stefanie; Kim, Dong Young; Hultquist, Judd F.; Shindo, Keisuke; LaRue, Rebecca S.; Kwon, Eunju; Li, Ming; Anderson, Brett D.; Yen, Linda (2011-12-21). "Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection". Nature. 481 (7381): 371–375. doi:10.1038/nature10693. ISSN 1476-4687. PMC 3310910. PMID 22190037.
  13. ^ "Acclaimed Molecular Biologist Named New QB3-UCSF Director". UC San Francisco. Retrieved 2017-02-01.
  14. ^ "Thermo Fisher Proteomics Facility for Disease Target Discovery opens at Gladstone". EurekAlert!. Retrieved 2017-02-01.
  15. ^ "Using big data to chart cancer's hidden genetic weaknesses". Retrieved 2017-02-01.
  16. ^ "UCSF, San Diego Researchers Challenging Status Quo On Cancer Treatments". Retrieved 2017-02-01.
  17. ^ "Sequencing Biology's Hottest, 2002-06".
  18. ^ "Searle Scholars Program : Nevan J. Krogan (2009)". www.searlescholars.net. Retrieved 2017-02-01.
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