Nizofenone

Nizofenone
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N06BX10 (WHO) ;
Identifiers
	IUPAC name (2-chlorophenyl)(2-{2-[(diethylamino)methyl]-1H-imidazol-1-yl}-5-nitrophenyl)methanone;
CAS Number	54533-85-6;
PubChem CID	4514;
ChemSpider	4357 ;
UNII	7A2NOC3R88;
CompTox Dashboard (EPA)	DTXSID401014745 DTXSID5048637, DTXSID401014745 ;
Chemical and physical data
Formula	C21H21ClN4O3
Molar mass	412.869 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccccc1C(=O)c3cc([N+]([O-])=O)ccc3n2ccnc2CN(CC)CC;
	InChI InChI=1S/C21H21ClN4O3/c1-3-24(4-2)14-20-23-11-12-25(20)19-10-9-15(26(28)29)13-17(19)21(27)16-7-5-6-8-18(16)22/h5-13H,3-4,14H2,1-2H3 ; Key:WZGBZLHGOVJDET-UHFFFAOYSA-N ;
	(verify)

Nizofenone (Ekonal, Midafenone) is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke.^[1]^[2]^[3]^[4]

References

^ Ohta T, Kikuchi H, Hashi K, Kudo Y. Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study. Journal of Neurosurgery. 1986 Mar;64(3):420-6. PMID 3512795
^ Yasuda H, Izumi N, Nakanishi M, Maruyama Y. Brain protection against oxygen deficiency by nizofenone. Advances in Experimental Medicine and Biology. 1988;222:403-10. PMID 3364265
^ Yasuda H, Nakajima A. Brain protection against ischemic injury by nizofenone. Cerebrovascular and Brain Metabolism Reviews. 1993 Winter;5(4):264-76. PMID 8110594
^ Matsumoto Y, Aihara K, Kamata T, Goto N. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. European Journal of Pharmacology. 1994 Sep 1;262(1-2):157-61. PMID 7813567

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[1] Ohta T, Kikuchi H, Hashi K, Kudo Y. Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study. Journal of Neurosurgery. 1986 Mar;64(3):420-6. PMID 3512795

[2] Yasuda H, Izumi N, Nakanishi M, Maruyama Y. Brain protection against oxygen deficiency by nizofenone. Advances in Experimental Medicine and Biology. 1988;222:403-10. PMID 3364265

[3] Yasuda H, Nakajima A. Brain protection against ischemic injury by nizofenone. Cerebrovascular and Brain Metabolism Reviews. 1993 Winter;5(4):264-76. PMID 8110594

[4] Matsumoto Y, Aihara K, Kamata T, Goto N. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. European Journal of Pharmacology. 1994 Sep 1;262(1-2):157-61. PMID 7813567

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