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O-aminophenol oxidase

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O-aminophenol oxidase
Identifiers
EC no.1.10.3.4
CAS no.9013-85-8
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O-aminophenol oxidase (EC 1.10.3.4, isophenoxazine synthase, o-aminophenol:O2 oxidoreductase, 2-aminophenol:O2 oxidoreductase, GriF) is an enzyme with systematic name 2-aminophenol:oxygen oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

2 2-aminophenol + O2 + acceptor 2-aminophenoxazin-3-one + reduced acceptor + 2 H2O (overall reaction)
(1a) 2 2-aminophenol + O2 2 6-iminocyclohexa-2,4-dienone + 2 H2O
(1b) 2 6-iminocyclohexa-2,4-dienone + acceptor 2-aminophenoxazin-3-one + reduced acceptor (spontaneous)

O-aminophenol oxidase is a flavoprotein.

References

  1. ^ Nair, P.M.; Vaidynathan, C.S. (1964). "Isophenoxazine synthase". Biochim. Biophys. Acta. 81: 507–516. doi:10.1016/0926-6569(64)90135-x. PMID 14170322.
  2. ^ Nair, P.M.; Vining, L.C. (1965). "Isophenoxazine synthase apoenzyme from Pycnoporus coccineus". Biochim. Biophys. Acta. 96: 318–327. doi:10.1016/0926-6593(65)90015-9. PMID 14298835.
  3. ^ Subba Rao, P.V.; Vaidyanathan, C.S. (1967). "Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra". Arch. Biochem. Biophys. 118 (2): 388–394. doi:10.1016/0003-9861(67)90365-7. PMID 4166439.
  4. ^ Suzuki, H.; Furusho, Y.; Higashi, T.; Ohnishi, Y.; Horinouchi, S. (2006). "A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone". J. Biol. Chem. 281 (2): 824–833. doi:10.1074/jbc.M505806200. PMID 16282322.{{cite journal}}: CS1 maint: unflagged free DOI (link)