OVGP1

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OVGP1
Identifiers
AliasesOVGP1, CHIT5, EGP, MUC9, OGP, oviductal glycoprotein 1
External IDsMGI: 106661 HomoloGene: 74442 GeneCards: OVGP1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OVGP1
Genomic location for OVGP1
Band1p13.2Start111,414,314 bp[1]
End111,427,777 bp[1]
RNA expression pattern
PBB GE OVGP1 205432 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002557

NM_007696

RefSeq (protein)

NP_002548

NP_031722

Location (UCSC)Chr 1: 111.41 – 111.43 MbChr 3: 105.97 – 105.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein (EGP) or mucin-9 (MUC9) is a protein that in humans is encoded by the OVGP1 gene.[5][6][7]

Function[edit]

Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoon acrosomal regions.[7] Beyond the oviduct, OVGP1 is detected in the mouse ovary, testis and epididymis suggesting its roles beyond fertilization. It is not detected in the mouse uterus, cervix, vagina, breast, seminal vesicles and prostate gland [8] OVGP1 is expressed by the surface epithelium of the endometrium at the time of embryo implantation in the mouse. It is required for maintain the receptivity phenotype and trophoblast adhesion, OVGP1 mRNA levels are reduced in endometrium of women with recurrent implantation failure [9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000085465 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074340 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod. 51 (4): 685–94. doi:10.1095/biolreprod51.4.685. PMID 7819450.
  6. ^ Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril. 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.
  7. ^ a b "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)".
  8. ^ Laheri, Saniya; Modi, Deepak; Bhatt, Purvi (Mar 2017). "Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary". Journal of Biosciences. 42 (1): 69–80. PMID 28229966. Retrieved 16 July 2018.
  9. ^ Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak. "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. doi:10.1007/s10815-018-1231-4. PMID 29968069.
  • Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak. "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. doi:10.1007/s10815-018-1231-4. PMID 29968069.

Further reading[edit]