Olke C. Uhlenbeck

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O. C. Uhlenbeck
Residence United States
Citizenship American
Fields Biochemistry
Institutions University of Illinois
University of Colorado
Northwestern University
Alma mater University of Michigan
Harvard University
Doctoral advisor Paul Doty
Known for RNA synthesis from synthetic templates, RNA-protein interactions, RNA Biochemistry
His father was the famous Physicist George Eugene Uhlenbeck.

Olke C. Uhlenbeck is a biochemist presently at Northwestern University.[1] He was elected to the United States National Academy of Sciences in 1993 [2] and has published over 200 peer-reviewed articles.[3] His research group has led to many breakthroughs in RNA biochemistry, most notably the enzymatic synthesis of RNAs from synthetic DNA templates using T7 RNA polymerase.[4] Olke was a founding member of the RNA society.[5]

Early Contributions[edit]

As a graduate student in Paul Doty's lab, Olke showed that the anticodon of tRNA was accessible to hybridization to oligonucleotides.[6] Later, as a Miller Research Fellow in Ignacio Tinoco, Jr.'s lab he helped define an original model for RNA secondary structure prediction.[7]

Contributions from the Uhlenbeck Lab[edit]

Olke is a longstanding contributor to RNA biochemistry. His group has shown many important findings as well as developed important tools for RNA biochemists. Notable contributions include:

See also[edit]

List of RNA biologists


  1. ^ "Northwestern University Department of Molecular Biosciences The Uhlenbeck Lab Home". Biochem.northwestern.edu. Retrieved 2011-03-02. 
  2. ^ "National Academy of Sciences:". Nasonline.org. Retrieved 2011-03-02. [not in citation given]
  3. ^ ""Uhlenbeck OC"[Author] - PubMed - NCBI". Ncbi.nlm.nih.gov. 2011-10-03. Retrieved 2011-12-02. 
  4. ^ Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405Freely accessible. PMID 3684574. [better source needed]
  5. ^ "An Imperfect Account of the Founding of the RNA Society". The RNA society. 
  6. ^ Uhlenbeck, Olke C.; Baller, Julie; Doty, Paul (1970). "Complementary Oligonucleotide Binding to the Anticodon Loop of fMet-transfer RNA". Nature. 225 (5232): 508–10. Bibcode:1970Natur.225..508U. doi:10.1038/225508a0. PMID 5411856. [better source needed]
  7. ^ Tinoco, Ignacio; Uhlenbeck, Olke C.; Levine, Mark D. (1971). "Estimation of Secondary Structure in Ribonucleic Acids". Nature. 230 (5293): 362–7. Bibcode:1971Natur.230..362T. doi:10.1038/230362a0. PMID 4927725. [better source needed]