An oncocyte is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. Oncocytes can be benign or can undergo malignant transformation.
Also known as:
- Hürthle cell (thyroid gland only)
- Oxyphilic cell,
- Askanazy cell,
- Apocrine metaplasia (breast gland only).
Derived from the Greek root onco-, which means mass, bulk.
- Oncocytoma, a tumour composed of oncocytes, may be found as a less common salivary gland neoplasm also known as Oxyphilic Adenoma.
- Renal oncocytoma, a kidney tumour composed of oncocytes.
- Hurthle cell carcinoma, a variant of follicular thyroid carcinoma).