PARD3B

PARD3B
Identifiers
Aliases	PARD3B, ALS2CR19, PAR3B, PAR3L, PAR3LC, PAR3beta, Par3Lb, par-3 family cell polarity regulator beta
External IDs	MGI: 1919301; HomoloGene: 35389; GeneCards: PARD3B; OMA:PARD3B - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	205,620,162 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	62,681,443 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ventricular zone; ; Achilles tendon; ; epithelium of colon; ; saphenous vein; ; tibial arteries; ; mucosa of ileum; ; testicle; ; gonad; ; skin of hip;
	Top expressed in
	Rostral migratory stream; ; crypt of lieberkuhn of small intestine; ; internal carotid artery; ; external carotid artery; ; sciatic nerve; ; lumbar spinal ganglion; ; renal corpuscle; ; ciliary body; ; iris; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylinositol binding;
Cellular component	membrane; endomembrane system; bicellular tight junction; cell junction; nucleoplasm; nuclear body; protein-containing complex; cytoplasm; adherens junction; cell cortex; apical plasma membrane; apical junction complex;
Biological process	cell division; cell cycle; microtubule cytoskeleton organization; cell adhesion; protein localization; establishment of cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; establishment of centrosome localization;
	Sources:Amigo / QuickGO
Orthologs
	117583
	72823
	ENSG00000116117
	ENSMUSG00000052062
	Q8TEW8
	Q9CSB4
	NM_001302769; NM_057177; NM_152526; NM_205863
	NM_001081050
	NP_001289698; NP_476518; NP_689739; NP_995585
	NP_001074519
	Wikidata
View/Edit Human	View/Edit Mouse

Partitioning defective 3 homolog B is a protein that in humans is encoded by the PARD3B gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

PARD3B has been shown to interact with Mothers against decapentaplegic homolog 3.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116117 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052062 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298.
^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem Biophys Res Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
^ "Entrez Gene: PARD3B par-3 partitioning defective 3 homolog B (C. elegans)".
^ Warner, Dennis R; Pisano M Michele; Roberts Emily A; Greene Robert M (Mar 2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3). Netherlands: 167–73. doi:10.1016/S0014-5793(03)00155-8. ISSN 0014-5793. PMID 12650946. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading