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Protocadherin alpha 1

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(Redirected from PCDHA1)
PCDHA1
Identifiers
AliasesPCDHA1, PCDH-ALPHA1, Protocadherin alpha 1
External IDsOMIM: 606307; MGI: 2150982; HomoloGene: 75093; GeneCards: PCDHA1; OMA:PCDHA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031411
NM_018900
NM_031410

NM_054072

RefSeq (protein)

NP_061723
NP_113598
NP_113599

n/a

Location (UCSC)Chr 5: 140.79 – 141.01 MbChr 18: 37.06 – 37.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protocadherin alpha-1 is a protein that in humans is encoded by the PCDHA1 gene.[5][6]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and two more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains, while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed, and additional variants have been suggested, but their full-length nature has yet to be determined.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204970Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000103442Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
  6. ^ a b "Entrez Gene: PCDHA1 protocadherin alpha 1".

Further reading

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