PDE1A

PDE1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LXQ
Identifiers
Aliases	PDE1A, CAM-PDE-1A, HCAM-1, HCAM1, HSphosphodiesterase 1A, CAM-PDE 1A
External IDs	OMIM: 171890; MGI: 1201792; HomoloGene: 21043; GeneCards: PDE1A; OMA:PDE1A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	182,523,359 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	79,959,802 bp
RNA expression pattern
	Top expressed in
	sperm; ; Brodmann area 23; ; buccal mucosa cell; ; middle temporal gyrus; ; renal medulla; ; entorhinal cortex; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; cerebellar cortex;
	Top expressed in
	spermatid; ; dentate gyrus of hippocampal formation granule cell; ; seminiferous tubule; ; right kidney; ; primary visual cortex; ; superior frontal gyrus; ; subiculum; ; anterior amygdaloid area; ; primary motor cortex; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; calmodulin binding; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytosol; cytoplasm; nucleus; soma;
Biological process	cGMP catabolic process; cAMP catabolic process; signal transduction; regulation of smooth muscle cell apoptotic process; regulation of smooth muscle cell proliferation; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5136
	18573
	ENSG00000115252
	ENSMUSG00000059173
	P54750; Q9Y633
	Q61481
NM_001003683; NM_001258312; NM_001258313; NM_001258314; NM_005019;
	NM_001363871; NM_001395258; NM_001395259; NM_001395260; NM_001395261; NM_001395262; NM_001395263; NM_001395264; NM_001395265; NM_001395266; NM_001395267; NM_001395268; NM_001395269
NM_001009978; NM_001009979; NM_001159582; NM_016744; NM_001355140;
	NM_001355141; NM_001355142; NM_001355143; NM_001355144
NP_001003683; NP_001245241; NP_001245242; NP_001245243; NP_005010;
	NP_001350800; NP_001245241.1
NP_001009978; NP_001009979; NP_001153054; NP_058024; NP_001342069;
	NP_001342070; NP_001342071; NP_001342073
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115252 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059173 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K (May 2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim Biophys Acta. 1517 (2): 278–87. doi:10.1016/s0167-4781(00)00293-1. PMID 11342109.
^ "Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent".

References

Further reading