PDE6A

PDE6A
Identifiers
Aliases	PDE6A, CGPR-A, PDEA, RP43, phosphodiesterase 6A
External IDs	OMIM: 180071; MGI: 97524; HomoloGene: 380; GeneCards: PDE6A; OMA:PDE6A - orthologs
EC number	3.1.4.35
Gene location (Human)
Chr.	Chromosome 5 (human)
End	149,944,793 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,422,995 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; rectum; ; pituitary gland; ; anterior pituitary; ; oral cavity; ; vulva; ; eyeball; ; retina; ; retinal pigment epithelium; ; muscle tissue;
	Top expressed in
	retinal pigment epithelium; ; secondary oocyte; ; spermatocyte; ; outer nuclear layer; ; kidney; ; extraocular muscle; ; renal cortex; ; proximal tubule; ; soleus muscle; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; 3',5'-cyclic-GMP phosphodiesterase activity; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding;
Cellular component	membrane; plasma membrane; photoreceptor disc membrane;
Biological process	response to stimulus; GMP metabolic process; regulation of cytosolic calcium ion concentration; visual perception; signal transduction; regulation of rhodopsin mediated signaling pathway; G protein-coupled receptor signaling pathway; rhodopsin mediated signaling pathway; retina development in camera-type eye; Wnt signaling pathway, calcium modulating pathway;
	Sources:Amigo / QuickGO
Orthologs
	5145
	225600
	ENSG00000132915
	ENSMUSG00000024575
	P16499
	P27664
	NM_000440
	NM_146086
	NP_000431
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE6A gene.^[5]^[6]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132915 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024575 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (Apr 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics. 6 (2): 272–83. doi:10.1016/0888-7543(90)90567-E. PMID 2155175.
^ "Entrez Gene: PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha".

External links

GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview

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This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132915 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024575 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2155175-5] Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (Apr 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics. 6 (2): 272–83. doi:10.1016/0888-7543(90)90567-E. PMID 2155175.

[entrez-6] "Entrez Gene: PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha".

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References

Further reading

External links