PEPCK-Cmus mice are genetically modified mice (Mus musculus) which as a result of their modification have up to 100 times the concentration of the PEPCK-C enzyme in their muscles, compared to ordinary mice.
They were created by a team of American scientists led by Richard Hanson, professor of biochemistry at Case Western Reserve University at Cleveland, Ohio, to gain a greater understanding of the PEPCK-C enzyme, which is present mainly in the liver and kidneys.
Professor Hanson noted that PEPCK-Cmus mice, dubbed "the mighty mice", "are metabolically similar to Lance Armstrong biking up the Pyrenees. They utilize mainly fatty acids for energy and produce very little lactic acid. Without eating or drinking, they can run for four or five hours. They are 10 times more active than ordinary mice in their home cage. They also live longer – up to three years of age – and are reproductively active for almost three years. In short, they are remarkable animals." However, "they eat twice as much as control mice, but they are half the weight, and are very aggressive. Why this is the case, we are not really sure."
- Hakimi, P.; Yang, J.; Casadesus, G.; Massillon, D.; Tolentino-Silva, F.; Nye, C. K.; Cabrera, M. E.; Hagen, D. R.; Utter, C. B.; Baghdy, Y.; Johnson, D. H.; Wilson, D. L.; Kirwan, J. P.; Kalhan, S. C.; Hanson, R. W. (23 August 2007). "Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse". Journal of Biological Chemistry. 282 (45): 32844–32855. doi:10.1074/jbc.M706127200. PMC 4484620. PMID 17716967.
- Hanson, R. W. & Hakimi, P. (2008). "Born to run; the story of the PEPCK-Cmus mouse". Biochimie. 90 (6): 383–42. doi:10.1016/j.biochi.2008.03.009. PMC 2491496. PMID 18394430.
- Connor, Steve (2007-11-02). "The mouse that shook the world". The Independent.
- Highfield, Roger (2007-11-02). "Genetically engineered 'mighty mouse' is the rodent Lance Armstrong". Telegraph.