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PHACTR3

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PHACTR3
Identifiers
AliasesPHACTR3, C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3
External IDsOMIM: 608725; MGI: 1921439; HomoloGene: 14482; GeneCards: PHACTR3; OMA:PHACTR3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001007154
NM_001177789
NM_001177790
NM_001177791
NM_028806

RefSeq (protein)

NP_001007155
NP_001171260
NP_001171261
NP_001171262
NP_083082

Location (UCSC)Chr 20: 59.58 – 59.85 MbChr 2: 177.76 – 177.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.[5][6]

Function

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The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.[6]

Interactions

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PHACTR3 has been shown to interact with PPP1CA.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087495Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027525Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A. 101 (18): 7187–92. Bibcode:2004PNAS..101.7187A. doi:10.1073/pnas.0401673101. PMC 406487. PMID 15107502.
  6. ^ a b "Entrez Gene: PHACTR3 phosphatase and actin regulator 3".
  7. ^ Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.

Further reading

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