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PIGF

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PIGF
Identifiers
AliasesPIGF, phosphatidylinositol glycan anchor biosynthesis class F, OORS
External IDsOMIM: 600153; MGI: 99462; HomoloGene: 31103; GeneCards: PIGF; OMA:PIGF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002643
NM_173074

NM_008838

RefSeq (protein)

NP_002634
NP_775097

NP_032864

Location (UCSC)Chr 2: 46.58 – 46.62 MbChr 17: 87.3 – 87.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.[5][6][7]

Function

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This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least two alternatively spliced transcripts encoding distinct isoforms have been found for this gene.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151665Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024145Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Oct 1995). "Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF". Genomics. 29 (3): 804–807. doi:10.1006/geno.1995.9929. PMID 8575782.
  6. ^ Inoue N, Kinoshita T, Orii T, Takeda J (Apr 1993). "Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy". The Journal of Biological Chemistry. 268 (10): 6882–6885. doi:10.1016/S0021-9258(18)53122-7. PMID 8463218.
  7. ^ a b "Entrez Gene: PIGF phosphatidylinositol glycan anchor biosynthesis, class F".

Further reading

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