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Phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Protein PIK3R3 PDB 2pna.png
PDB rendering based on 2pna.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PIK3R3 ; p55; p55-GAMMA; p55PIK
External IDs OMIM606076 MGI109277 HomoloGene2690 GeneCards: PIK3R3 Gene
RNA expression pattern
PBB GE PIK3R3 202743 at tn.png
PBB GE PIK3R3 211580 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8503 18710
Ensembl ENSG00000117461 ENSMUSG00000028698
UniProt Q92569 Q64143
RefSeq (mRNA) NM_001114172 NM_181585
RefSeq (protein) NP_001107644 NP_853616
Location (UCSC) Chr 1:
46.04 – 46.13 Mb
Chr 4:
116.22 – 116.3 Mb
PubMed search [1] [2]

Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.[1][2]


PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor,[3] IRS1[3][4] and Retinoblastoma protein.[5]


  1. ^ Dey BR, Furlanetto RW, Nissley SP (May 1998). "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor". Gene 209 (1–2): 175–83. doi:10.1016/S0378-1119(98)00045-6. PMID 9524259. 
  2. ^ "Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)". 
  3. ^ a b Mothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. (UNITED STATES) 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. ISSN 0888-8809. PMID 9415396. 
  4. ^ Xia, X; Serrero G (Aug 1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. (ENGLAND) 341 (3): 831–7. doi:10.1042/0264-6021:3410831. ISSN 0264-6021. PMC 1220424. PMID 10417350. 
  5. ^ Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. (United States) 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. ISSN 0270-7306. PMC 151709. PMID 12588990. 

Further reading[edit]