PIP4K2B

PIP4K2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BO1, 3WZZ, 3X01, 3X02, 3X03, 3X04, 3X05, 3X06, 3X07, 3X08, 3X09, 3X0A, 3X0B, 3X0C
Identifiers
Aliases	PIP4K2B, PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
External IDs	OMIM: 603261 MGI: 1934234 HomoloGene: 2634 GeneCards: PIP4K2B
Gene location (Human)
Chr.	Chromosome 17 (human)
End	38,800,126 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,635,530 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Brodmann area 9; ; prefrontal cortex; ; cerebellar hemisphere; ; muscle of leg; ; Achilles tendon; ; gastrocnemius muscle; ; amygdala; ; stromal cell of endometrium; ; nucleus accumbens;
	Top expressed in
	internal carotid artery; ; superior frontal gyrus; ; external carotid artery; ; hand; ; gastrocnemius muscle; ; foot; ; facial motor nucleus; ; piriform cortex; ; knee joint; ; hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; kinase activity; phosphatidylinositol phosphate kinase activity; protein binding; ATP binding; 1-phosphatidylinositol-3-phosphate 4-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; protein homodimerization activity;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; plasma membrane; autophagosome; endoplasmic reticulum; nucleus; nucleoplasm;
Biological process	phosphatidylinositol metabolic process; positive regulation of autophagosome assembly; phosphorylation; cell surface receptor signaling pathway; regulation of autophagy; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphate biosynthetic process; regulation of phosphatidylinositol 3-kinase signaling; phospholipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8396
	108083
	ENSG00000277292; ENSG00000276293
	ENSMUSG00000018547
	P78356
	Q80XI4
	NM_003559; NM_138687
	NM_054051
	NP_003550
	NP_473392
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.^[5]^[6]^[7]^[8]

Template:PBB Summary

Interactions

PIP4K2B has been shown to interact with TNFRSF1A.^[5] In addition, PIP4K2B has been shown to interact with PIP4K2A and may modulate the cellular localisation of PIP4K2A.^[9]

Structure

The structure of PIP4K2B has been determined through X-ray crystallography.^[10]

References

^ ^a ^b ^c ENSG00000276293 GRCh38: Ensembl release 89: ENSG00000277292, ENSG00000276293 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018547 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem. 272 (9): 5861–70. doi:10.1074/jbc.272.9.5861. PMID 9038203.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene. 23 (7): 1354–63. doi:10.1038/sj.onc.1207251. PMID 14691457.
^ Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. doi:10.1038/36621. PMID 9367159.
^ "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".
^ Bultsma, Yvette; Keune, Willem-Jan; Divecha, Nullin (2010-09-01). "PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα". Biochemical Journal. 430 (2): 223–235. doi:10.1042/bj20100341. ISSN 0264-6021. PMID 20583997.
^ Rao, Vibha D; Misra, Saurav; Boronenkov, Igor V; Anderson, Richard A; Hurley, James H. "Structure of Type IIβ Phosphatidylinositol Phosphate Kinase". Cell. 94 (6): 829–839. doi:10.1016/s0092-8674(00)81741-9.

Interactions

Structure

References

Further reading