PLEKHG5
Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene.[5] Multiple transcript variants encoding different isoforms have been found for this gene.
Function
This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway.[5]
Clinical significance
Mutations in the PLEKHG5 gene are associated with distal spinal muscular atrophy type 4.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171680 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039713 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Pleckstrin homology domain containing, family G (with RhoGef domain) member 5".
This article incorporates text from the United States National Library of Medicine, which is in the public domain.