PLOD3

PLOD3
Identifiers
Aliases	PLOD3, LH3, procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
External IDs	OMIM: 603066; MGI: 1347008; HomoloGene: 843; GeneCards: PLOD3; OMA:PLOD3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	101,218,420 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,025,502 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; pancreatic ductal cell; ; tibial nerve; ; mucosa of transverse colon; ; C1 segment; ; body of uterus; ; granulocyte; ; upper lobe of left lung; ; muscle layer of sigmoid colon; ; right lobe of liver;
	Top expressed in
	granulocyte; ; calvaria; ; yolk sac; ; stroma of bone marrow; ; ankle joint; ; tibiofemoral joint; ; gastrula; ; lactiferous gland; ; muscle of thigh; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; L-ascorbic acid binding; dioxygenase activity; metal ion binding; protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; procollagen galactosyltransferase activity; oxidoreductase activity; procollagen-lysine 5-dioxygenase activity; procollagen glucosyltransferase activity; catalytic activity; transferase activity; glycosyltransferase activity;
Cellular component	rough endoplasmic reticulum membrane; endoplasmic reticulum membrane; membrane; extracellular exosome; endoplasmic reticulum; Golgi apparatus; trans-Golgi network; extracellular matrix; extracellular region; extracellular space; endoplasmic reticulum lumen; rough endoplasmic reticulum; collagen-containing extracellular matrix;
Biological process	protein localization; lung morphogenesis; collagen fibril organization; epidermis morphogenesis; endothelial cell morphogenesis; vasodilation; in utero embryonic development; basement membrane assembly; cellular response to hormone stimulus; neural tube development; protein O-linked glycosylation; hydroxylysine biosynthetic process; peptidyl-lysine hydroxylation; collagen metabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	8985
	26433
	ENSG00000106397
	ENSMUSG00000004846
	O60568
	Q9R0E1
	NM_001084
	NM_011962
	NP_001075
	NP_036092
	Wikidata
View/Edit Human	View/Edit Mouse

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 is an enzyme that in humans is encoded by the PLOD3 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106397 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004846 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Passoja K, Rautavuoma K, Ala-Kokko L, Kosonen T, Kivirikko KI (Sep 1998). "Cloning and characterization of a third human lysyl hydroxylase isoform". Proc Natl Acad Sci U S A. 95 (18): 10482–6. doi:10.1073/pnas.95.18.10482. PMC 27920. PMID 9724729.
^ Valtavaara M, Szpirer C, Szpirer J, Myllyla R (Jun 1998). "Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3)". J Biol Chem. 273 (21): 12881–6. doi:10.1074/jbc.273.21.12881. PMID 9582318.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3".

References

Further reading