Jump to content

POLR2J2

From Wikipedia, the free encyclopedia
POLR2J2
Identifiers
AliasesPOLR2J2, polymerase (RNA) II (DNA directed) polypeptide J2, HRPB11B, RPB11b1, polymerase (RNA) II subunit J2, RNA polymerase II subunit J2, RPB11b2, POLR2J3
External IDsOMIM: 609881; HomoloGene: 129653; GeneCards: POLR2J2; OMA:POLR2J2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145325
NM_032958
NM_032959

n/a

RefSeq (protein)

NP_001091084
NP_116581

n/a

Location (UCSC)Chr 7: 102.67 – 102.67 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.[3]

This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J.

Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.[3]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000228049Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene".

Further reading

[edit]