PPP1R12B

PPP1R12B
Identifiers
Aliases	PPP1R12B, MYPT2, PP1bp55, protein phosphatase 1 regulatory subunit 12B
External IDs	OMIM: 603768; MGI: 1916417; HomoloGene: 136757; GeneCards: PPP1R12B; OMA:PPP1R12B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,592,706 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,883,680 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; myocardium of left ventricle; ; right coronary artery; ; cardiac muscle tissue of right atrium; ; right ventricle; ; popliteal artery; ; tibial arteries; ; tail of epididymis; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	Rostral migratory stream; ; ascending aorta; ; muscle of thigh; ; aortic valve; ; soleus muscle; ; extraocular muscle; ; digastric muscle; ; temporal muscle; ; vastus lateralis muscle; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	enzyme activator activity; protein binding; protein kinase binding; phosphatase regulator activity; enzyme inhibitor activity;
Cellular component	cytoplasm; cytosol; A band; Z disc; nucleoplasm; cytoskeleton;
Biological process	regulation of muscle contraction; positive regulation of catalytic activity; signal transduction; regulation of catalytic activity; negative regulation of catalytic activity; G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	4660
	329251
	ENSG00000077157
	ENSMUSG00000073557
	O60237
	Q8BG95
NM_001167857; NM_001167858; NM_001197131; NM_002481; NM_032103;
	NM_032104; NM_032105; NM_001331029
	NM_001081307; NM_001368827; NM_001368829
NP_001161329; NP_001161330; NP_001184060; NP_001317958; NP_002472;
	NP_115286; NP_115287
	NP_001074776; NP_001355756; NP_001355758
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1 regulatory subunit 12B is an enzyme that in humans is encoded by the PPP1R12B gene.^[5]^[6]

Template:PBB Summary

Interactions

PPP1R12B has been shown to interact with Interleukin 16.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077157 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073557 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fujioka M, Takahashi N, Odai H, Araki S, Ichikawa K, Feng J, Nakamura M, Kaibuchi K, Hartshorne DJ, Nakano T, Ito M (Jun 1998). "A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping". Genomics. 49 (1): 59–68. doi:10.1006/geno.1998.5222. PMID 9570949.
^ "Entrez Gene: PPP1R12B protein phosphatase 1, regulatory (inhibitor) subunit 12B".
^ Bannert, Norbert; Vollhardt Karin; Asomuddinov Bakhtier; Haag Marion; König Herbert; Norley Stephen; Kurth Reinhard (Oct 2003). "PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits". J. Biol. Chem. 278 (43). United States: 42190–9. doi:10.1074/jbc.M306669200. ISSN 0021-9258. PMID 12923170. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading