Protein phosphatase 1 regulatory subunit 12c

PPP1R12C
Identifiers
Aliases	PPP1R12C, LENG3, MBS85, p84, p85, protein phosphatase 1 regulatory subunit 12C, AAVS1
External IDs	OMIM: 613245; MGI: 1924258; HomoloGene: 75071; GeneCards: PPP1R12C; OMA:PPP1R12C - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,117,637 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,504,679 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; muscle layer of sigmoid colon; ; body of uterus; ; apex of heart; ; left testis; ; canal of the cervix; ; right testis; ; left uterine tube; ; popliteal artery; ; tibial arteries;
	Top expressed in
	granulocyte; ; neural layer of retina; ; superior frontal gyrus; ; interventricular septum; ; lip; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; cerebellar cortex; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase binding; protein binding; phosphatase regulator activity; enzyme inhibitor activity;
Cellular component	cytoplasm; cytoskeleton;
Biological process	signal transduction; regulation of catalytic activity; negative regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	54776
	232807
	ENSG00000125503
	ENSMUSG00000019254
	Q9BZL4
	Q3UMT1
	NM_001271618; NM_017607
	NM_029834
	NP_001258547; NP_060077
	NP_084110
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1 regulatory subunit 12C is a protein that in humans is encoded by the PPP1R12C gene. ^[5]

Function

The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125503 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019254 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Protein phosphatase 1 regulatory subunit 12C". Retrieved 2016-11-14.

Function

References

Further reading