Patchoulol synthase

Patchoulol synthase (EC 4.2.3.70) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

\rightleftharpoons

References

^ Croteau, R.; Munck, S.L.; Akoh, C.C.; Fisk, H.J.; Satterwhite, D.M. (1987). "Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations". Arch. Biochem. Biophys. 256: 56–68. doi:10.1016/0003-9861(87)90425-5. PMID 3038029.
^ Munck, S.L.; Croteau, R. (1990). "Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin". Arch. Biochem. Biophys. 282: 58–64. doi:10.1016/0003-9861(90)90086-e. PMID 2171435.
^ Faraldos, J.A.; Wu, S.; Chappell, J.; Coates, R.M. (2010). "Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-²H₁]farnesyl diphosphate catalyzed by recombinant patchoulol synthase". J. Am. Chem. Soc. 132: 2998–3008. doi:10.1021/ja909251r. PMID 20148554.

Patchoulol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase
4.2.2: Acting on polysaccharides	Hyaluronate lyase Pectin lyase
4.2.3: Acting on phosphates	Threonine synthase
4.2.99: Other	Carboxymethyloxysuccinate lyase Hydroperoxide lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)