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Pauline Rudd

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Pauline Rudd
FRSM
Born
Pauline Mary Rudd
EducationBournemouth School for Girls
Alma materWestfield College (BSc)
Open University (PhD)
Scientific career
FieldsGlycobiology
InstitutionsUniversity College Dublin
University College Cork
University of Oxford
Scripps Research
Ben-Gurion University of the Negev
Wessex Biochmeicals
ThesisThe structure and function of glycoforms (1995)
Doctoral advisorPeter Taylor[1]
Websiteapc.ucc.ie/pauline-rudd/ Edit this at Wikidata

Pauline Rudd FRSM is a British biochemist and Professor at the Microbiome Institute, University College Cork.[2] She is a founder of Wessex Biochemicals, a Fellow of the Royal Society of Medicine and was awarded the James Gregory Medal in 2010.[3]

Early life and education

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Rudd grew up in Bournemouth and attended Bournemouth School for Girls. As a child she wanted to be a physicist. Her uncle was a physicist, and Rudd joined the British Junior Astronomical Association. She was the only girl in a group of 48 boys, and said she was never allowed to look down the telescope.[4] The male dominated environment of physics made Rudd consider a career in chemistry instead.[4] When she was fourteen, she started to use washing machines and liquidisers to create rare sugars and sugar phosphates. She sold these chemicals through and co-founded Wessex Biochemicals.[4][5] Rudd was an undergraduate chemistry student at Westfield College, then part of the University of London.[4] After earning her degree, she joined Wessex Biochemicals which employed thirty people before being acquired by Sigma-Aldrich.[when?][4] She completed her PhD in 1995 which was awarded by the Open University.[1]

Research and career

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Rudd joined the glycobiology institute at the University of Oxford in 1985. At the time, it was difficult for women scientists to secure jobs as academic personnel, and Rudd joined as a glass washer. She learned how to work with glycoproteins and large sugars and eventually completed a doctorate on glycoforms at the Open University in 1995.[1] Rudd moved to the Scripps Research institute, and held a visiting position at the Ben-Gurion University of the Negev. She commercialised her work on liquid chromatography–mass spectrometry (LCMS) with Waters Corporation.[citation needed]

Rudd has worked to miniaturise technologies for glycol analysis. For example, she has used genome-wide association studies (GWAS) to link individual genomes to their serum glycome and individual proteins.[6] She moved to University College Dublin in 2006, where was made head of the Dublin-Oxford glycobiology laboratory research group.[7][8] She opened the National Institute for Bioprocessing Research and Training (NIBRT), where she developed new processes for protein glycosylation in an attempt to characterise recombinant protein drugs.[9]

Awards and honours

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Selected publications

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  • Rudd PM; Elliott T; Cresswell P; Wilson IA; Dwek RA (1 March 2001). "Glycosylation and the immune system". Science. 291 (5512): 2370–2376. doi:10.1126/SCIENCE.291.5512.2370. ISSN 0036-8075. PMID 11269318. Wikidata Q34195578.
  • James N Arnold; Mark R Wormald; Robert B. Sim; Pauline M Rudd; Raymond A Dwek (1 January 2007). "The impact of glycosylation on the biological function and structure of human immunoglobulins". Annual Review of Immunology. 25: 21–50. doi:10.1146/ANNUREV.IMMUNOL.25.022106.141702. ISSN 0732-0582. PMID 17029568. Wikidata Q36618276.
  • Van den Steen P; Rudd PM; Dwek RA; Opdenakker G (1 January 1998). "Concepts and principles of O-linked glycosylation". Critical Reviews in Biochemistry and Molecular Biology. 33 (3): 151–208. doi:10.1080/10409239891204198. ISSN 1040-9238. PMID 9673446. Wikidata Q34749639.

Personal life

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Rudd serves as an associate of the Anglican Church at the Community of St Mary the Virgin in Wantage, Oxfordshire.[14] She took a fifteen-year career break to raise her four children.[4]

References

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  1. ^ a b c Rudd, Pauline Mary (1995). The structure and function of glycoforms. open.ac.uk (PhD thesis). Open University. doi:10.21954/ou.ro.0000fb9f. OCLC 556507763. EThOS uk.bl.ethos.295604. Open access icon
  2. ^ Pauline Rudd publications from Europe PubMed Central
  3. ^ a b "James Gregory Lectures on Science, Religion and Human Flourishing | Is there more to life than genes?". jamesgregory.org.uk. Retrieved 2022-06-11.
  4. ^ a b c d e f "The Science of Sugar: Lessons Learned with Pauline Rudd". The Medicine Maker. Retrieved 2022-06-11.
  5. ^ "Professor Pauline M. Rudd". Jenner Symposium. Retrieved 2022-06-11.
  6. ^ a b "Pauline Rudd". The Analytical Scientist. Retrieved 2022-06-11.
  7. ^ a b c "Fellows". International Society for Science & Religion (ISSR). Retrieved 2022-06-11.
  8. ^ "Celtic strength: Science in Ireland". science.org. Retrieved 2022-06-11.
  9. ^ "Agilent | Agilent Technologies, National Institute for Bioprocessing Research and Training, Advance Emerging Glycomics Research". agilent.com. 2010-06-29. Retrieved 2022-06-11.
  10. ^ "Agilent Thought Leader Program". agilent.com. 2021-09-30. Retrieved 2022-06-11.
  11. ^ Bulletin, Laboratory News from Lab. "Waters Selects Ireland's NIBRT and Prof. Pauline Rudd for Center of Innovation Program Honors". labbulletin.com. Retrieved 2022-06-11.
  12. ^ "Honorary Doctors at Sahlgrenska Academy | University of Gothenburg". gu.se. Retrieved 2022-06-11.
  13. ^ Sonnino, Sandro (2019-08-01). "The international Glycoconjugate organization awards". Glycoconjugate Journal. 36 (4): 237. doi:10.1007/s10719-019-09877-z. ISSN 1573-4986. PMID 31267249. S2CID 195774182.
  14. ^ Priest, Eric (2016-08-18). Reason and Wonder: Why Science And Faith Need Each Other. SPCK. ISBN 978-0-281-07525-6.
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