DeBusk was born and raised in Rose Hill, Virginia, where he graduated from Thomas Walker High School. After graduating from Lincoln Memorial University, DeBusk began his career in 1965 as a pharmaceutical salesman and regional sales manager. In 1973 DeBusk patented his first medical product, an orthopedic boot, and founded DeRoyal Industries.
DeBusk self-published a book in 2013, "The Rabbit's Got the Gun: The Deroyal Industries Story," which recounts his business career.
As the chairman of the Lincoln Memorial University Board of Trustees and a member of MedPAC Commission, DeBusk co-founded the Lincoln Memorial University DeBusk College of Osteopathic Medicine in 2007. The Lincoln Memorial University- John J. Duncan, Jr. School of Law, also co-founded by Debusk, was subsequently denied provisional accreditation by the American Bar Association. However, in the Fall of 2015, the law school received provisional accreditation from the American Bar Association. 
- Official WebsiteDeRoyal Executives
- Katie Porterfield, DeRoyal Treatment, Business TN, April 2008
- Spoke Public Records
- Genera Energy
- All Business, A D&B CompanyPublication:Business Wire June 3, 2003
- Lincoln Memorial University Official WebsiteAbout LMU-DCOM 2010