Phorbol-12-myristate-13-acetate-induced protein 1
Template:PBB Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.[1][2][3] Template:PBB Summary Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.[4] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.
Interactions
Noxa has been shown to interact with MCL1,[5][6] BCL2-like 1[5][7] and Bcl-2.[5][7]
See also
- Apoptosis
- Apoptosome
- Bcl-2
- Bcl-2-associated X protein (BAX)
- BH3 interacting domain death agonist (BID)
- Caspases
- Cytochrome c
- Mitochondrion
- p53 upregulated modulator of apoptosis (PUMA)
- 12-O-Tetradecanoylphorbol-13-acetate (Phorbol-12-myristate-13-acetate)
References
- ^ Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K (October 1990). "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line". J Virol. 64 (10): 4632–9. PMC 247947. PMID 2398525.
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: CS1 maint: multiple names: authors list (link) - ^ Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene. 22 (30): 4675–8. doi:10.1038/sj.onc.1206655. PMID 12879012.
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: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1".
- ^
Oda, E. (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–1058. doi:10.1126/science.288.5468.1053. PMID 10807576.
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: Unknown parameter|coauthors=
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Further reading
External links
- NOXA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)