Phorbol 12,13-dibutyrate
Appearance
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Names | |
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Other names
Phorbol dibutyrate; Phorbol 12,13-dibutanoate
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Identifiers | |
3D model (JSmol)
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Abbreviations | PDBu |
ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.164.231 |
KEGG | |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C28H40O8 | |
Molar mass | 504.620 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phorbol 12,13-dibutyrate (PDBu) is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate.[1]
PDBu is widely used as a chemical reagent because of its solubility in water and other organic solvents.
References
- ^ Blumberg PM, Delclos KB, Dunn JA, Jaken S, Leach KL, Yeh E (1983). "Phorbol ester receptors and the in vitro effects of tumor promoters". Annals of the New York Academy of Sciences. 407: 303–315. doi:10.1111/j.1749-6632.1983.tb47836.x. PMID 6309054.