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Physical urticaria

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Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical stimulus rather than occurring spontaneously.[1] There are seven subcategories that are recognized as independent diseases.[2][3] Physical urticaria is known to be a painful, itchy and physically unappealing; which can recur for months to years of a person's life.[4]

Physical urticaria, more specifically dermatographism

Sub-categories

There are seven sub-categories of physical urticaria:

Signs and symptoms

Characterized by dermal edema (wheal) and erthema (flare) also known as hives.[2] Hive lesions typically last less than 24 and are usually pruritic.[2] Hives can appear on anywhere on the body and they may change shape, move around, disappear and reappear over short periods of time.[5]

Types of hives

Acute urticaria (short-term): can develop suddenly and will last less than 6 weeks.[6] About 1 in 6 people will have acute hives at one point in their life.[6]

Chronic urticaria (long-term): can develop suddenly and will persist more than 6 weeks.[6] This type of urticaria is uncommon[6] and occurs in only 0.1% of the population.[7] 20% of people with chronic urticaria report still having problems 10 years after its onset.[7]

Causes

The cause of physical urticaria is unknown but it has been suggested to be an autoimmune disease. Suggesting that antibodies, which are produced by the immune system to protect humans from foreign microbes, are binding to body tissue; damaging body tissue.[8]

In some cases physical urticaria can be a symptom of an underlying health issue such as:[9]

Or can also be due to:[10]

  • food allergies
  • atopy

Treatment

Antihistamine agents are the typically prescribed drug for the treatment of physical urticaria.[2] They block the effect of histamine, a compound produced by the body which forms a part of the local immune response consequently causing inflammation.[6] Some research has suggested that the use antihistamines and antagonist in synergy are better for the treatment of physical urticarias.[11][12]

The cascade of events that link the autoantibody-antigen reaction with the production and release of histamine is not well characterized. Therefore, the focus of treatment for physical urticaria has been on characterizing the effectiveness of antihistamines rather than analysis of receptor binding or the pathomechanisms.[10][13]

See also

References

  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 265, 266, 267–8. ISBN 1-4160-2999-0.
  2. ^ a b c d e Lee, Ernest E.; Maibach, Howard I. (February 2001). "Treatment of Urticaria: An evidence-based evaluation of Antihistamines". American Journal of Clinical Dermatology. 2 (1): p27-32. doi:10.2165/00128071-200102010-00005. Retrieved 24 April 2016. {{cite journal}}: |pages= has extra text (help)
  3. ^ a b Beate, Henz (2000). "Antihistamines and Alternatives in Physical Urticaria". Dermatologic Therapy.
  4. ^ Martina, Kozel; Mekkes, Jan; bossuyt, patrick (October 2001). "Natural course of physical and chronic urticaria and angioedema in 220 patients". Journal of the American Academy of Dermatology. PMID 11511835.
  5. ^ "Hives (Urticaria)". ACAAI. Retrieved 2016-04-24.
  6. ^ a b c d e "Hives (urticaria). What are hives? Treatment for hives. | Patient". Patient. Retrieved 2016-04-25.
  7. ^ a b Katelaris, Connie (October 2001). "Treatment of Urticaria". Australian Prescriber. 24 (5). Retrieved 24 April 2016.
  8. ^ CL, Goh; Kt, Tan (2009). "Chronic Autoimmune Urticaria : Where We Stand ?". Indian Journal of Dermatology. PMID 20161862.
  9. ^ "Hives and Your Skin". WebMD. Retrieved 2016-04-25.
  10. ^ a b Grattan C, Black AK. Urticaria and angioedema. In: Bolognia JL, Jorrizo JL, Rapini RP, editors. Dermatology. Vol. 1. London: Elsevier, 2003: 287–302
  11. ^ Breathnach SM, Allen R, Ward AM, et al. Symptomatic dermatographism: Natural history, clinical features, laboratory investigations and response to therapy. Clin Exp Dermatol 1983; 8 (5): 463-76
  12. ^ Kaur, Surrinder, Malcolm Greaves, and Nahid Eftekhari. "Factitious Urticaria (dermographism): Treatment by Cimetidine and Chlorpheniramine in a Randomized Double-blind Study." Br J Dermatol British Journal of Dermatology 104.2 (1981): 185-90. Web.
  13. ^ Grattan, C (2003). Bolognia; Jorrizo; Rapini (eds.). "Urticaria and angioedema". London: Elsevier. 1: 287–302.
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