Mannuronate-specific alginate lyase

poly(beta-D-mannuronate) lyase
Identifiers
EC no.	4.2.2.3
CAS no.	9024-15-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Alginate_lyase2
crystal structure of alginate lyase pa1167 from pseudomonas aeruginosa at 2.0 a resolution
Identifiers
Symbol	Alginate_lyase2
Pfam	PF08787
InterPro	IPR014895
SCOP2	1uai / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Alginate_lyase
Identifiers
Symbol	Alginate_lyase
Pfam	PF05426
SCOP2	1uai / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In enzymology, a poly(beta-D-mannuronate) lyase (EC 4.2.2.3) is an enzyme that catalyzes the chemical reaction

Eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is poly(beta-D-1,4-mannuronide) lyase. Other names in common use include alginate lyase I, alginate lyase, alginase I, alginase II, and alginase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HV6, 1J1T, and 2CWS.

References

• Davidson IW, Lawson CJ, Sutherland IW (1977). "An alginate lysate from Azotobacter vinelandii phage". J. Gen. Microbiol. 98 (1): 223–9. doi:10.1099/00221287-98-1-223. PMID 13144.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Nakada HI, Sweeny PC (1967). "Alginic acid degradation by eliminases from abalone hepatopancreas". J. Biol. Chem. 242 (5): 845–51. PMID 6020438.
• Preiss J; Ashwell G (1962). "Alginic acid metabolism in bacteria. I. Enzymatic formation of unsaturated oligosaccharides and 4-deoxy-L-erythro-5-hexoseulose uronic acid". J. Biol. Chem. 237: 309–316.