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Poorly differentiated thyroid cancer

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Poorly differentiated thyroid carcinoma
SpecialtyOncology Edit this on Wikidata

Poorly differentiated thyroid carcinoma (PDTC) is malignant neoplasm of follicular cell origin showing intermediate histopathological patterns between differentiated and undifferentiated thyroid cancers.[1]

Histopathological features

  • Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern
  • Round or oval nests (insulae) or in trabeculae.
  • Solid growth and presence of microfollicles, some of which contain dense colloid.
  • Extrathyroidal extension and blood vessel invasion
  • Foci of necrosis,
  • Larger than 5 cm in greatest diameter at diagnosis

Clinical features

  • PDTC affects predominantly females about 55 years of age
  • Both local and distant (lung, bone, brain)

References

  1. ^ Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, Katoh R, Lloyd RV, LiVolsi VA, Papotti M, Sobrinho-Simoes M, Bussolati G, Rosai J (2007). "Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach". Am J Surg Pathol. 31 (8): 1256–64. doi:10.1097/PAS.0b013e3180309e6a. PMID 17667551.


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