Pristane
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| Names | |
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| IUPAC name
2,6,10,14-Tetramethylpentadecane[1]
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| Identifiers | |
3D model (JSmol)
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| 1720538 | |
| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | 100.016.047 |
| EC Number |
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| MeSH | pristane |
PubChem CID
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| RTECS number |
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C19H40 | |
| Molar mass | 268.529 g·mol−1 |
| Appearance | Colorless liquid |
| Odor | Odorless |
| Density | 783 mg mL−1 |
| Melting point | −100.0 °C; −147.9 °F; 173.2 K |
| Boiling point | 296 °C (565 °F; 569 K) |
Refractive index (nD)
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1.438 |
| Thermochemistry | |
Heat capacity (C)
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569.76 J K−1 mol−1 |
| Hazards | |
| GHS labelling: | |
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| Warning | |
| H315 | |
| Flash point | >110 °C |
| Related compounds | |
Related alkanes
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pristane is a natural saturated terpenoid alkane obtained primarily from shark liver oil, from which its name is derived (Latin pristis, "shark"). It is also found in the stomach oil of birds in the order Procellariiformes and in mineral oil and some foods.[2] Pristane and phytane are used in the fields of geology and environmental science as biomarkers to characterize origins and evolution of petroleum hydrocarbons and coal.[3]
It is a transparent oily liquid that is immiscible with water, but soluble in diethyl ether, benzene, chloroform and carbon tetrachloride.
Pristane is known to induce autoimmune diseases in rodents. It is used in research to understand the pathogenesis of rheumatoid arthritis and lupus.[4][5][6]
It is used as a lubricant, a transformer oil, an immunologic adjuvant, and an anti-corrosion agent, biological marker, plasmocytomas inducer and in production of monoclonal antibodies.
Biosynthetically, pristane is derived from phytol and is used as a biomarker in petroleum studies.[7] Tocopherols represent an alternate sedimentary source of pristane in sediments and petroleum.[8]
Toxicity of pristane alleviated by aconitine.[9]
References
- ^ "pristane - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 26 March 2005. Identification and Related Records.
- ^ Chung, J.-G; Garrett, L.R; Byers, P.E; Cuchens, M.A (1989). "A survey of the amount of pristane in common fruits and vegetables". Journal of Food Composition and Analysis. 2 (1): 22–7. doi:10.1016/0889-1575(89)90058-6.
- ^ Brooks, J. D.; Gould, K.; Smith, J. W. (April 1969). "Isoprenoid Hydrocarbons in Coal and Petroleum". Nature. 222 (5190): 257–259. doi:10.1038/222257a0.
- ^ Anderson, Paul N; Potter, Michael (1969). "Induction of Plasma Cell Tumours in BALB/c Mice with 2,6,10,14-Tetramethylpentadecane (Pristane)". Nature. 222 (5197): 994–5. Bibcode:1969Natur.222..994A. doi:10.1038/222994a0. PMID 5789334.
- ^ Hazani, Ron; Engineer, Nitin (2008). "Surreptitious Injection of Mineral Oil". Annals of Plastic Surgery. 61 (5): 555–8. doi:10.1097/SAP.0b013e31816d8316. PMID 18948786.
- ^ Hahn, Bevra Hannahs; Kono, Dwight (2013). "Animal Models of SLE". Dubois' Lupus Erythematosus and Related Syndromes. pp. 190–236. doi:10.1016/B978-1-4377-1893-5.00017-0. ISBN 978-1-4377-1893-5.
- ^ Hunt, John M; Philp, R.Paul; Kvenvolden, Keith A (2002). "Early developments in petroleum geochemistry". Organic Geochemistry. 33 (9): 1025–52. doi:10.1016/S0146-6380(02)00056-6.
- ^ Goossens, H; De Leeuw, J. W; Schenck, P. A; Brassell, S. C (1984). "Tocopherols as likely precursors of pristane in ancient sediments and crude oils". Nature. 312 (5993): 440–2. Bibcode:1984Natur.312..440G. doi:10.1038/312440a0.
- ^ Li, Xiaodong; Gu, Liwei; Yang, Lan; Zhang, Dong; Shen, Jianying (2017). "Aconitine: A potential novel treatment for systemic lupus erythematosus". Journal of Pharmacological Sciences. 133 (3): 115–121. doi:10.1016/j.jphs.2017.01.007. PMID 28302448.