Proglucagon
Proglucagon is a protein that is cleaved from preproglucagon. Preproglucagon in humans is encoded by the GCG gene.[1][2]
Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon. It is cleaved into the following components:
- Glicentin
- Glicentin-related pancreatic polypeptide (GRPP)
- Oxyntomodulin (OXY or OXM)
- Glucagon
- Glucagon-like peptide 1 (GLP-1)
- Glucagon-like peptide 2 (GLP-2)
References
- ^ Schroeder WT, Lopez LC, Harper ME, Saunders GF (1984). "Localization of the human glucagon gene (GCG) to chromosome segment 2q36–37". Cytogenet. Cell Genet. 38 (1): 76–9. doi:10.1159/000132034. PMID 6546710.
- ^ White JW, Saunders GF (June 1986). "Structure of the human glucagon gene". Nucleic Acids Res. 14 (12): 4719–30. doi:10.1093/nar/14.12.4719. PMC 311486. PMID 3725587.
