Prolactin-releasing peptide

PRLH
Identifiers
Aliases	PRLH, PRH, PRRP, prolactin releasing hormone
External IDs	OMIM: 602663; MGI: 3644668; HomoloGene: 9291; GeneCards: PRLH; OMA:PRLH - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	237,567,175 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	90,881,749 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; tendon of biceps brachii; ; right auricle; ; skin of thigh; ; right uterine tube; ; optic nerve; ; face; ; sensory organ; ; lower respiratory tract; ; mucosa of nose;
	Top expressed in
	blastocyst; ; granulocyte; ; bone marrow; ; cerebellar cortex; ; colon; ; hypothalamus; ; duodenum; ; human kidney; ; proximal tubule; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neuropeptide hormone activity; prolactin-releasing peptide receptor binding; hormone activity;
Cellular component	cytoplasm; extracellular region;
Biological process	tissue homeostasis; reduction of food intake in response to dietary excess; energy reserve metabolic process; lipid metabolism; G protein-coupled receptor signaling pathway; response to glucose; response to insulin; regulation of multicellular organism growth; fat cell differentiation; autonomic nervous system development; response to dietary excess; response to peptide hormone; eating behavior; feeding behavior; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	51052
	623503
	ENSG00000071677
	ENSMUSG00000090550
	P81277
	G3UWC3
	NM_015893
	NM_001101647
	NP_056977
	NP_001095117
	Wikidata
View/Edit Human	View/Edit Mouse

Prolactin-releasing peptide (PrRP) is a peptide hormone that in humans is encoded by the PRLH gene.^[5] PrRP stimulates prolactin (PRL) release and regulates the expression of prolactin through binding to the prolactin-releasing peptide receptor (GPR10).^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000071677 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090550 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PRLH prolactin releasing hormonel".
^ Langmead CJ, Szekeres PG, Chambers JK, Ratcliffe SJ, Jones DN, Hirst WD, Price GW, Herdon HJ (October 2000). "Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor". Br. J. Pharmacol. 131 (4): 683–8. doi:10.1038/sj.bjp.0703617. PMC 1572376. PMID 11030716.

Hinuma S, Onda H, Fujino M (1999). "The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors". J. Mol. Med. 77 (6): 495–504. doi:10.1007/s001090050403. PMID 10475064.
Lagerström MC, Fredriksson R, Bjarnadottir TK, Schiöth HB (2006). "The ancestry of the prolactin-releasing hormone precursor". Ann. N. Y. Acad. Sci. 1040: 368–70. doi:10.1196/annals.1327.064. PMID 15891064.
Hinuma S, Habata Y, Fujii R, et al. (1998). "A prolactin-releasing peptide in the brain". Nature. 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.
Fujii R, Fukusumi S, Hosoya M, et al. (1999). "Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor". Regul. Pept. 83 (1): 1–10. doi:10.1016/S0167-0115(99)00028-2. PMID 10498338.
Zhang X, Danila DC, Katai M, et al. (2000). "Expression of prolactin-releasing peptide and its receptor messenger ribonucleic acid in normal human pituitary and pituitary adenomas". J. Clin. Endocrinol. Metab. 84 (12): 4652–5. doi:10.1210/jc.84.12.4652. PMID 10599733.
Yasui Y, Yamaguchi M, Jikihara H, et al. (2002). "Expression of prolactin-releasing peptide in human placenta and decidua". Endocr. J. 48 (3): 397–401. doi:10.1507/endocrj.48.397. PMID 11523913.
Takahashi K, Totsune K, Murakami O, et al. (2003). "Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas". Peptides. 23 (6): 1135–40. doi:10.1016/S0196-9781(02)00046-3. PMID 12126742.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000071677 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090550 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PRLH prolactin releasing hormonel".

[pmid11030716-6] Langmead CJ, Szekeres PG, Chambers JK, Ratcliffe SJ, Jones DN, Hirst WD, Price GW, Herdon HJ (October 2000). "Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor". Br. J. Pharmacol. 131 (4): 683–8. doi:10.1038/sj.bjp.0703617. PMC 1572376. PMID 11030716.

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References

Further reading