RABAC1 is a gene that in humans encodes the protein Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1.[5][6][7] It is highly conserved in eukaryotes.[5] The protein is localized to Golgi[8] and late endosomes,[9] where it plays a role in vesicular trafficking, lipid transport and cell migration.[10]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcBucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB (May 1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochemical and Biophysical Research Communications. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID10329441.
^Hutt DM, Da-Silva LF, Chang LH, Prosser DC, Ngsee JK (Jun 2000). "PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1". The Journal of Biological Chemistry. 275 (24): 18511–9. doi:10.1074/jbc.M909309199. PMID10751420.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
^ abMartincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID9341137.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Further reading
Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID9341137.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC (Jan 2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon". Neuron. 25 (1): 203–14. doi:10.1016/S0896-6273(00)80883-1. PMID10707984.
Figueroa C, Taylor J, Vojtek AB (Jul 2001). "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases". The Journal of Biological Chemistry. 276 (30): 28219–25. doi:10.1074/jbc.M101763200. PMID11335720.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Bucci C, De Gregorio L, Bruni CB (Aug 2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochemical and Biophysical Research Communications. 286 (4): 815–9. doi:10.1006/bbrc.2001.5466. PMID11520070.
Blancou P, Evans DT, Desrosiers RC (Jun 2005). "PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation". The Journal of General Virology. 86 (Pt 6): 1785–90. doi:10.1099/vir.0.80873-0. PMID15914857.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID16169070.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Fo CS, Coleman CS, Wallick CJ, Vine AL, Bachmann AS (Apr 2006). "Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2)". Gene. 371 (1): 154–65. doi:10.1016/j.gene.2005.12.009. PMID16481131.
Kim JT, Cho MY, Choi SC, Kim JW, Chae SK, Yoon DY, Kim JW, Lim JS (Oct 2006). "Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin". Biochemical and Biophysical Research Communications. 349 (1): 200–8. doi:10.1016/j.bbrc.2006.08.026. PMID16930546.
