RAP1GAP

RAP1GAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SRQ, 3BRW
Identifiers
Aliases	RAP1GAP, RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP, RAP1 GTPase activating protein
External IDs	OMIM: 600278; MGI: 109338; HomoloGene: 2163; GeneCards: RAP1GAP; OMA:RAP1GAP - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	21,669,363 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,729,861 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; left lobe of thyroid gland; ; nucleus accumbens; ; right lobe of thyroid gland; ; parotid gland; ; putamen; ; caudate nucleus; ; middle frontal gyrus; ; right frontal lobe; ; external globus pallidus;
	Top expressed in
	superior frontal gyrus; ; habenula; ; primary visual cortex; ; nucleus accumbens; ; nucleus of stria terminalis; ; perirhinal cortex; ; olfactory tubercle; ; entorhinal cortex; ; parotid gland; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; GTPase regulator activity; protein binding; GTPase activity; GTPase activator activity;
Cellular component	Golgi apparatus; membrane; Golgi membrane; cytosol;
Biological process	negative regulation of microvillus assembly; regulation of GTPase activity; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	5909
	110351
	ENSG00000076864
	ENSMUSG00000041351
	P47736
	A2ALS5
NM_001145657; NM_001145658; NM_002885; NM_001330383; NM_001350524;
	NM_001350525; NM_001350526; NM_001350527; NM_001350528
	NM_001081155; NM_001256218; NM_029563; NM_001331215
NP_001139129; NP_001139130; NP_001317312; NP_002876; NP_001337453;
	NP_001337454; NP_001337455; NP_001337456; NP_001337457
NP_001074624; NP_001243147; NP_001318144; NP_083839; NP_001366162;
	NP_001366163; NP_001366164; NP_001366165
	Wikidata
View/Edit Human	View/Edit Mouse

Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene.^[5]^[6]

Template:PBB Summary

Interactions

RAP1GAP has been shown to interact with MLLT4.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076864 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041351 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P (Jul 1991). "Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1". Cell. 65 (6): 1033–42. doi:10.1016/0092-8674(91)90555-D. PMID 1904317.
^ "Entrez Gene: RAP1GAP RAP1 GTPase activating protein".
^ Su, Li; Hattori Masakazu; Moriyama Masaki; Murata Norihito; Harazaki Masashi; Kaibuchi Kozo; Minato Nagahiro (Apr 2003). "AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1". J. Biol. Chem. 278 (17). United States: 15232–8. doi:10.1074/jbc.M211888200. ISSN 0021-9258. PMID 12590145. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading