RARS (gene)

RARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Q2T, 4Q2X, 4Q2Y, 4R3Z, 4ZAJ
Identifiers
Aliases	RARS1, ArgRS, DALRD1, HLD9, arginyl-tRNA synthetase, arginyl-tRNA synthetase 1, RARS
External IDs	OMIM: 107820; MGI: 1914297; HomoloGene: 68281; GeneCards: RARS1; OMA:RARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	168,519,301 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	35,725,333 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; jejunal mucosa; ; rectum; ; islet of Langerhans; ; duodenum; ; body of pancreas; ; gonad; ; stromal cell of endometrium; ; skin of leg; ; skin of abdomen;
	Top expressed in
	tail of embryo; ; primitive streak; ; genital tubercle; ; hair follicle; ; epiblast; ; gastrula; ; endothelial cell of lymphatic vessel; ; yolk sac; ; crypt of lieberkuhn of small intestine; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; tRNA binding; arginine binding; ligase activity; protein binding; ATP binding; cadherin binding; arginine-tRNA ligase activity;
Cellular component	membrane; nucleoplasm; mitochondrion; extracellular exosome; nucleus; cytoplasm; aminoacyl-tRNA synthetase multienzyme complex; cytosol;
Biological process	protein biosynthesis; tRNA aminoacylation for protein translation; arginyl-tRNA aminoacylation;
	Sources:Amigo / QuickGO
Orthologs
	5917
	104458
	ENSG00000113643
	ENSMUSG00000018848
	P54136
	Q9D0I9
	NM_002887
	NM_025936
	NP_002878
	NP_080212
	Wikidata
View/Edit Human	View/Edit Mouse

Arginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the RARS gene.^[5]^[6]

Template:PBB Summary

Genetics

Mutations in RARS cause Template:SWL.^[7]

Interactions

RARS (gene) has been shown to interact with QARS.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113643 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018848 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Girjes AA, Hobson K, Chen P, Lavin MF (December 1995). "Cloning and characterization of cDNA encoding a human arginyl-tRNA synthetase". Gene. 164 (2): 347–50. doi:10.1016/0378-1119(95)00502-W. PMID 7590355.
^ "Entrez Gene: RARS arginyl-tRNA synthetase".
^ Wolf, N. I.; Salomons, G. S.; Rodenburg, R. J.; Pouwels, P. J.; Schieving, J. H.; Derks, T. G.; Fock, J. M.; Rump, P; Van Beek, D. M.; Van Der Knaap, M. S.; Waisfisz, Q (2014). "Mutations in RARS cause hypomyelination". Annals of Neurology. 76 (1): 134–9. doi:10.1002/ana.24167. PMID 24777941.
^ Kim, T; Park S G; Kim J E; Seol W; Ko Y G; Kim S (July 2000). "Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex". J. Biol. Chem. 275 (28). UNITED STATES: 21768–72. doi:10.1074/jbc.M002404200. ISSN 0021-9258. PMID 10801842. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Genetics

Interactions

References

Further reading