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RASGRF2

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RASGRF2
Identifiers
AliasesRASGRF2, GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2
External IDsOMIM: 606614; MGI: 109137; HomoloGene: 2169; GeneCards: RASGRF2; OMA:RASGRF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006909

NM_009027

RefSeq (protein)

NP_008840

NP_033053

Location (UCSC)Chr 5: 80.96 – 81.23 MbChr 13: 92.03 – 92.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.[5]

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM][5]

Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113319Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021708Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2".
  6. ^ "Binge Drinking Gene: RASGRF-2 Helps Explain Teenage Alcohol Abuse, Scientists Say". Huffington Post. 3 December 2012.

Further reading

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