Reticulocalbin 2

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RCN2
Identifiers
AliasesRCN2, E6BP, ERC-55, ERC55, TCBP49, reticulocalbin 2
External IDsMGI: 1349765 HomoloGene: 2176 GeneCards: RCN2
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for RCN2
Genomic location for RCN2
Band15q24.3Start76,931,738 bp[1]
End76,954,393 bp[1]
RNA expression pattern
PBB GE RCN2 201486 at fs.png

PBB GE RCN2 201485 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002902
NM_001271837

NM_001278274
NM_011992

RefSeq (protein)

NP_001258766
NP_002893

NP_001265203
NP_036122

Location (UCSC)Chr 15: 76.93 – 76.95 MbChr 9: 56.04 – 56.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Reticulocalbin-2 is a protein that in humans is encoded by the RCN2 gene.[5][6][7]

Reticulocalbin 2 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. The RCN2 gene maps to the same region as type 4 Bardet-Biedl syndrome (MIM:600374), suggesting a possible causative role for reticulocalbin 2 in the disorder.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117906 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032320 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Wang JY, Zhen DK, Bianchi DW, Androphy EJ, Chen JJ (Apr 1998). "Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33→q24.1 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 60–1. doi:10.1159/000134683. PMID 9533013.
  6. ^ Chen JJ, Reid CE, Band V, Androphy EJ (Aug 1995). "Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein". Science. 269 (5223): 529–31. doi:10.1126/science.7624774. PMID 7624774.
  7. ^ a b "Entrez Gene: RCN2 reticulocalbin 2, EF-hand calcium binding domain".

Further reading[edit]