RDH8

RDH8
Identifiers
Aliases	RDH8, PRRDH, SDR28C2, retinol dehydrogenase 8 (all-trans), retinol dehydrogenase 8
External IDs	OMIM: 608575; MGI: 2685028; HomoloGene: 41062; GeneCards: RDH8; OMA:RDH8 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,022,279 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	20,737,413 bp
RNA expression pattern
	Top expressed in
	sperm; ; right testis; ; left testis; ; retinal pigment epithelium; ; islet of Langerhans; ; human kidney; ; sural nerve; ; cecum; ; breast; ; mammary gland;
	Top expressed in
	neural layer of retina; ; hypothalamus; ; muscle of thigh; ; lens; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; NADP-retinol dehydrogenase activity; estradiol 17-beta-dehydrogenase activity; NAD-retinol dehydrogenase activity;
Cellular component	cytoplasm; integral component of membrane; integral component of plasma membrane; membrane;
Biological process	estrogen biosynthetic process; retinol metabolic process; response to stimulus; visual perception; steroid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	50700
	235033
	ENSG00000080511
	ENSMUSG00000053773
	Q9NYR8
	D3Z6W3
	NM_015725
	NM_001030290
	NP_056540
	NP_001025461
	Wikidata
View/Edit Human	View/Edit Mouse

Retinol dehydrogenase 8 is an enzyme that in humans is encoded by the RDH8 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080511 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053773 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rattner A, Smallwood PM, Nathans J (May 2000). "Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol". J Biol Chem. 275 (15): 11034–11043. doi:10.1074/jbc.275.15.11034. PMID 10753906.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: RDH8 retinol dehydrogenase 8 (all-trans)".